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Risk Association Of Tox3 And Mmp7 Gene Polymorphisms With Sporadic Breast Cancer In Mexican Women, Orlando Solis-Coronado, Mónica Patricia Villarreal-Vela, Hazyadee Frecia Rodríguez-Gutiérrez, Juan Francisco González-Guerrero, Ricardo M. Cerda-Flores, Fernando Alcorta-Núñez, Karen Paola Camarillo-Cárdenas, Diana Cristina Pérez-Ibave, Oscar Vidal-Gutiérrez, Genaro A. Ramírez-Correa, María Lourdes Garza-Rodríguez

School of Medicine Publications and Presentations

Breast cancer (BC) has one of the highest incidences and mortality worldwide. Single nucleotide polymorphisms (SNPs) in TOX3 rs3803662 and MMP7 rs1943779 have been associated with susceptibility to BC. In this case-control study, we evaluated the association of rs3803662 (TOX3)/rs1943779 (MMP7) SNPs with clinical features, immunohistochemical reactivity, and risk association with BC in women from northeastern Mexico. We compared 212 BC cases and 212 controls. DNA was isolated from peripheral blood to perform the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. We calculated genotype frequencies, odds ratios, and 95% confidence intervals. We found that CT …