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Open-Angle Glaucomatous Optic Neuropathy Is Related To Dips Rather Than Increases In The Mean Arterial Pressure Over 24-H, Jesus D. Melgarejo, Jan V. Eijgen, Gladys E. Maestre, Lama A. Al-Aswad, Lutgarde Thijs, Luis J. Mena, Joseph D. Terwilliger, Michele Petitto, Carlos A. Chavez, Miguel Brito
Open-Angle Glaucomatous Optic Neuropathy Is Related To Dips Rather Than Increases In The Mean Arterial Pressure Over 24-H, Jesus D. Melgarejo, Jan V. Eijgen, Gladys E. Maestre, Lama A. Al-Aswad, Lutgarde Thijs, Luis J. Mena, Joseph D. Terwilliger, Michele Petitto, Carlos A. Chavez, Miguel Brito
School of Medicine Publications and Presentations
Background
Mean arterial pressure (MAP) drives ocular perfusion. Excessive 24-h MAP variability relates to glaucoma, however, whether this is due to dips or increases in the blood pressure (BP) is undocumented. We investigated the association of open-angle glaucoma (OAG) in relation to the five largest MAP dips/increases over 24-h, henceforth called dips/blips.
Methods
In the Maracaibo Aging Study (MAS), 93 participants aged ≥40y (women, 87.1%; mean age, 61.9y) underwent baseline ophthalmological and 24-h ambulatory BP monitoring assessments. OAG was the presence of optic nerve damage and visual field defects. Statistical methods included logistic regression and the generalized R2 statistic. …