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- Neoplastic/*genetics;; Genomics/methods;; Histones/*metabolism;; Humans;; Immunohistochemistry;; Molecular Sequence Data;; Mutation/genetics;; Neurilemmoma/*genetics;; Neurofibromin 1/genetics;; Polycomb Repressive Complex 2/*genetics/metabolism;; Real-Time Polymerase Chain Reaction;; Sequence Analysis (1)
- PET/CT;; treatment planning;; tumor delineation;; lung cancer;; TO-BACKGROUND RATIO;; COMPUTED-TOMOGRAPHY;; FDG-PET;; F-18-FDG PET;; NODAL;; VOLUMES;; CANCER NSCLC;; RADIOTHERAPY;; CT;; MOTION;; DELINEATION (1)
- Tcga;; gene expression;; glioblastoma;; prognostic genes (1)
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Prc2 Is Recurrently Inactivated Through Eed Or Suz12 Loss In Malignant Peripheral Nerve Sheath Tumors, W. Lee, S. Teckie, T. Wiesner, A. Viale, S. Singer, D. Zheng, M. F. Berger, Y. Chen, C. R. Antonescu, P. Chi, +11 Additional Authors
Prc2 Is Recurrently Inactivated Through Eed Or Suz12 Loss In Malignant Peripheral Nerve Sheath Tumors, W. Lee, S. Teckie, T. Wiesner, A. Viale, S. Singer, D. Zheng, M. F. Berger, Y. Chen, C. R. Antonescu, P. Chi, +11 Additional Authors
Journal Articles
Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1 associated) or after radiotherapy. Using comprehensive genomic approaches, we identified loss-of-function somatic alterations of the Polycomb repressive complex 2 (PRC2) components (EED or SUZ12) in 92% of sporadic, 70% of NF1-associated and 90% of radiotherapy-associated MPNSTs. MPNSTs with PRC2 loss showed complete loss of trimethylation at lysine 27 of histone H3 (H3K27me3) and aberrant transcriptional activation of multiple PRC2-repressed homeobox master regulators and their regulated developmental pathways. Introduction of the lost PRC2 component in a …
Transcriptional Diversity Of Long-Term Glioblastoma Survivors, N. K. Gerber, A. Goenka, S. Turcan, M. Reyngold, V. Makarov, K. Kannan, K. Beal, C. W. Brennan, J. T. Huse, T. A. Chan, +3 Additional Authors
Transcriptional Diversity Of Long-Term Glioblastoma Survivors, N. K. Gerber, A. Goenka, S. Turcan, M. Reyngold, V. Makarov, K. Kannan, K. Beal, C. W. Brennan, J. T. Huse, T. A. Chan, +3 Additional Authors
Journal Articles
BACKGROUND: Glioblastoma (GBM) is a highly aggressive type of glioma with poor prognosis. However, a small number of patients live much longer than the median survival. A better understanding of these long-term survivors (LTSs) may provide important insight into the biology of GBM. METHODS: We identified 7 patients with GBM, treated at Memorial Sloan-Kettering Cancer Center (MSKCC), with survival >48 months. We characterized the transcriptome of each patient and determined rates of MGMT promoter methylation and IDH1 and IDH2 mutational status. We identified LTSs in 2 independent cohorts (The Cancer Genome Atlas [TCGA] and NCI Repository for Molecular Brain Neoplasia …
Defining Internal Target Volume Using Positron Emission Tomography For Radiation Therapy Planning Of Moving Lung Tumors, A. C. Riegel, M. K. Bucci, O. R. Mawlawi, M. Ahmad, D. Luo, A. Chandler, T. S. Pan
Defining Internal Target Volume Using Positron Emission Tomography For Radiation Therapy Planning Of Moving Lung Tumors, A. C. Riegel, M. K. Bucci, O. R. Mawlawi, M. Ahmad, D. Luo, A. Chandler, T. S. Pan
Journal Articles
Substantial disagreement exists over appropriate PET segmentation techniques for non-small cell lung cancer. Currently, no segmentation algorithm explicitly considers tumor motion in determining tumor borders. We developed an automatic PET segmentation model as a function of target volume, motion extent, and source-to-background ratio (the VMSBR model). The purpose of this work was to apply the VMSBR model and six other segmentation algorithms to a sample of lung tumors. PET and 4D CT were performed in the same imaging session for 23 patients (24 tumors) for radiation therapy planning. Internal target volumes (ITVs) were autosegmented on maximum intensity projection (MIP) of …
B Cells Populating The Multiple Sclerosis Brain Mature In The Draining Cervical Lymph Nodes, J. N. Stern, G. Yaari, J. A. Vander Heiden, G. Church, W. F. Donahue, R. Q. Hintzen, A. J. Huttner, J. D. Laman, R. M. Nagra, K. C. O’Connor, +7 Additional Authors
B Cells Populating The Multiple Sclerosis Brain Mature In The Draining Cervical Lymph Nodes, J. N. Stern, G. Yaari, J. A. Vander Heiden, G. Church, W. F. Donahue, R. Q. Hintzen, A. J. Huttner, J. D. Laman, R. M. Nagra, K. C. O’Connor, +7 Additional Authors
Journal Articles
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of patients with MS harbors expanded clones of antigen-experienced B cells that reside in distinct compartments including the meninges, cerebrospinal fluid (CSF), and parenchyma. It is not understood whether this immune infiltrate initiates its development in the CNS or in peripheral tissues. B cells in the CSF can exchange with those in peripheral blood, implying that CNS B cells may have access to lymphoid tissue that may be the specific compartment(s) in which CNS-resident B cells encounter antigen and …