Medicine and Health Sciences Commons^™

Genome-Wide Meta-Analyses Identify Three Loci Associated With Primary Biliary Cirrhosis, Xiangdong Liu, Pietro Invernizzi, Yue Lu, Roman Kosoy, Yan Lu, Ilaria Bianchi, Mauro Podda, Chun Xu

Health & Biomedical Sciences Faculty Publications and Presentations

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

The Role Of Fat Mass Index In Determining Obesity, Gerson Peltz, Maria Teresa Aguirre, Maureen Sanderson, Mary K. Fadden

Health & Biomedical Sciences Faculty Publications and Presentations

Objectives: The objective of this study is to compare body mass index (BMI), percent body fat (PBF), and fat mass index (FMI) and to investigate the accuracy of FMI as a convenient tool for assessing obesity.

Design: Anthropometric measurements and bioelectrical impedance analyses were performed on 538 Mexican Americans (373 women and 165 men). Correlations between BMI and PBF and between FMI and PBF were investigated. The percentage of persons misclassified as obese using different classifications was calculated. Multiple linear regression analysis was performed to generate predictive models of FMI for males and females separately.

Results: BMI and PBF were …