Medicine and Health Sciences Commons^™

Growth Regulation Of Pancreatic Cancer Cells And Their Normal Cells Of Origin By Nicotinic Acetylcholine Receptors, Mohammed Hussein Al-Wadei

Doctoral Dissertations

Pancreatic cancer is the fourth leading cause of cancer mortality with a five-year survival rate of less than 5 %. It shows no symptoms until it has reached an advanced stage upon which it has metastasized to distant organs limiting therapeutic options. Several studies have identified smoking, alcohol, diabetes and pancreatitis as risk factors for pancreatic cancer. While smoking is a well-documented risk factor for this malignancy, there still remains a controversy on whether alcohol can act as a risk factor itself or cooperatively enhances the effects of other risk factors.

Previous reports provide evidence that nicotinic acetylcholine receptors (nAChRs) …

The Relationship Of Basic Conditioning Factors, Knowledge, Self-Care Agency, Self-Care Behavior, And Urinary Sodium Excretion Of Hypertensive Older Adults: Testing Orem’S Self-Care Theory, Pratsani Srikan

Doctoral Dissertations

Understanding the powerful factors of sodium reduction benefits older adults by leading to reduce many health risks, lower the health care cost and diminished economic and social burden. This study had two aims: 1) to explore to what degree four factors--selected basic conditioning factors, knowledge of sodium reduction, sodium reduction self-care agency, and sodium reduction self-care behavior predict urinary sodium excretion in hypertensive seniors, 2) to test whether these variables related to sodium reduction were congruent with Orem’s Self-Care Theory.

Based on this theory, internal and external conditioning factors were proposed as either positively or negatively influencing an individual’s knowledge …

Effects Of Increased Step Width On Knee Joint Biomechanics In Healthy And Knee Osteoarthritis Older Adults During Stair Descent, Maxime Robert Paquette

Doctoral Dissertations

Stair negotiation is one of the most challenging tasks for older adults especially for those suffering from knee osteoarthritis (OA). To date, no studies have investigated the effects of increased step width (SW) on knee joint biomechanics. The purpose of Study One was to investigate the effects of increased SW on peak internal knee abduction moment and other lower extremity variables during stair descent in healthy older adults. The purpose of Study Two was to investigate the effects of increased SW on peak internal knee abduction moment, knee pain and other lower extremity variables during stair descent in medial compartment …