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Full-Text Articles in Medicine and Health Sciences
Assessing Cognitive Health Outcomes In Anca-Associated Vasculitis Patients, Ruo Yan Chen
Assessing Cognitive Health Outcomes In Anca-Associated Vasculitis Patients, Ruo Yan Chen
Undergraduate Student Research Internships Conference
Anti-neutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare and life-threatening autoimmune disease with severe complications. Central nervous system (CNS) involvement is thought to be rare, however, the prevalence of neuropsychiatric complications have been reported in 30-60% of AAV cases. Studies looking at the cognitive health outcomes of AAV patients with CNS involvement have noted cognitive impairment as a significant contributor to reduced quality of life with unique challenges in care and treatment. The data collected from this primary output could be combined with global assessments of cognitive function as well as the application of advanced imaging tools to study …
Assessment Of Executive Function Using A Series Of Operant Conditioning Based Tasks In T1dm Rodents, Kevin T. Murphy
Assessment Of Executive Function Using A Series Of Operant Conditioning Based Tasks In T1dm Rodents, Kevin T. Murphy
Electronic Thesis and Dissertation Repository
This study examined the impact of Type 1 Diabetes Mellitus (T1DM) on executive function using a series of operant conditioning based tasks in rats. Sprague Dawley rats were randomized to either non-diabetic (n = 12; 6 male) or diabetic (n = 14; 6 male) groups. Diabetes was induced using multiple low-dose streptozotocin injections. All diabetic rodents were insulin-treated using subcutaneous insulin pellet implants. At week 14 of the study, rats were placed on a food restricted diet to induce 5 - 10% weight loss. Rodents were familiarized and tested on a series of tasks that required continuous adjustments to novel …