Medicine and Health Sciences Commons^™

Covid-19 And Chronic Diabetes: The Perfect Storm For Reactivation Tb?, Genesis P. Aguillón-Durán, Ericka Prieto-Martinez, Doris Ayala, Juan Garcia Jr, John M. Thomas, Juan I. Garcia, Jordi B. Torrelles, Eder Ledezma-Campos, Blanca I. Restrepo

Research Symposium

Background: The Coronavirus disease 2019 (COVID-19) pandemic is predicted to have a net negative effect on tuberculosis (TB) control, with an estimated excess of 6.3 million tuberculosis cases and 1.4 million deaths by 2025. Programmatic issues like the lockdown of TB services affect all patients, while biosocial factors have a differential impact on an individual’s risk for TB or adverse TB outcomes.

Case presentation: We report three cases of incident TB after resolution of COVID-19 episodes.Coincidently, all cases shared a common risk factor: a chronic history poorly-controlled diabetes.

Conclusions: Our findings alert to the threat posed by …

Looking For Crumbs In The Obesity Forest: Anti-Obesity Interventions And Obesity-Associated Cardiometabolic Traits In The Mexican Population. History And Systematic Review With Meta-Analyses, Esperanza M. Garcia-Oropesa, Yoscelina E. Martinez-Lopez, Sonia María Ruiz-Cejudo, José Darío Martínez-Ezquerro, Alvaro Diaz-Badillo, Carlos Ramirez-Pfeiffer, Alejandra Bustamante-Fuentes, Elena B. Lopez-Sosa, Oscar O. Moctezuma-Chavez, Edna J. Nava-Gonzalez, Adriana L. Perales-Torres, Lucia M. Perez-Navarro, Marisol Rosas-Diaz, Kathleen V. Carter, Beatriz Tapia, Juan C. Lopez-Alvarenga

School of Medicine Publications and Presentations

Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic …

Association Of Hiv-1 Infection And Antiretroviral Therapy With Type 2 Diabetes In The Hispanic Population Of The Rio Grande Valley, Texas, Usa, Juan Carlos Lopez Alvarenga, Dora A. Martinez, Alvaro Diaz-Badillo, Liza D. Morales, Rector Arya, Christopher Jenkinson, Joanne E. Curran, John Blangero, Ravi Duggirala, Srinivas Mummidi, Ruben D. Martinez

School of Medicine Publications and Presentations

The Rio Grande Valley (RGV) in South Texas has one of the highest prevalence of obesity and type 2 diabetes (T2D) in the United States (US). We report for the first time the T2D prevalence in persons with HIV (PWH) in the RGV and the interrelationship between T2D, cardiometabolic risk factors, HIV-related indices, and antiretroviral therapies (ART). The PWH in this study received medical care at Valley AIDS Council (VAC) clinic sites located in Harlingen and McAllen, Texas. Henceforth, this cohort will be referred to as Valley AIDS Council Cohort (VACC). Cross-sectional analyses were conducted using retrospective data obtained from …

The Re-Emerging Association Between Tuberculosis And Diabetes: Lessons From Past Centuries, Jose Cadena, Selvalakshmi Rathinavelu, Juan Carlos Lopez Alvarenga, Blanca I. Restrepo

School of Medicine Publications and Presentations

The association between tuberculosis (TB) and diabetes mellitus (DM) had a common place in the literature up to the first half of the 20th century, but virtually disappeared with the discovery of insulin to treat DM and antibiotics to cure TB. In the late 1990s the literature began to re-emerge with the worldwide increase in type 2 DM, particularly in TB-endemic countries. Today, type 2 DM is the most prevalent comorbidity among TB patients and the World Health Organization considers it a threat to TB control. We summarize the literature on TB and DM up to the 1960s. Then we …

Genetic Correlation Of The Plasma Lipidome With Type 2 Diabetes, Prediabetes And Insulin Resistance In Mexican American Families, Hemant Kulkarni, Manju Mamtani, Gerard Wong, Jacquelyn M. Weir, Christopher K. Barlow, Thomas D. Dyer, Laura Almasy, Michael Mahaney, Anthony G. Comuzzie, Ravindranath Duggirala, Peter J. Meikle, John Blangero, Joanne E. Curran

School of Medicine Publications and Presentations

Background

Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits.

Results

We used plasma lipidomic data (1202 pedigreed individuals, 319 lipid species representing 23 lipid classes) from San Antonio Family Heart Study in Mexican Americans. Bivariate trait analyses were used to estimate the genetic and environmental correlation of all lipid species with three T2D-related traits: risk of T2D, …

Genetic Variants In Kcnj11, Tcf7l2 And Hnf4a Are Associated With Type 2 Diabetes, Bmi And Dyslipidemia In Families Of Northeastern Mexico: A Pilot Study, Hugo Leonid Gallardo-Blanco, Jesus Zacarias Villarreal-Perez, Ricardo Martin Cerda-Flores, Andres Figueroa

Computer Science Faculty Publications and Presentations

The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low‑density lipoprotein (LDL), very LDL (VLDL), high‑density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11 …