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Full-Text Articles in Medicine and Health Sciences
The Apolipoprotein Ε4 Allele In Parkinson's Disease With And Without Dementia, K. Marder, Gladys E. Maestre, L. Cote, H. Mejia, B. Alfaro, A. Halim, M. Tang, B. Tycko, R. Mayeux
The Apolipoprotein Ε4 Allele In Parkinson's Disease With And Without Dementia, K. Marder, Gladys E. Maestre, L. Cote, H. Mejia, B. Alfaro, A. Halim, M. Tang, B. Tycko, R. Mayeux
School of Medicine Publications and Presentations
The ϵ4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein ϵ4 (Apoϵ4) in demented PD patients compared with nondemented PD patients and controls. The ϵ4 allele frequency for PD without dementia was 0.132, …