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Full-Text Articles in Medicine and Health Sciences
Chronic Constant Light Exposure Aggravates High Fat Diet-Induced Renal Injury In Rats, Lin Xing, Shanyu Wu, Ying Shi, Fangzhi Yue, Lin Wei, Ryan D. Russell, Dongmei Zhang
Chronic Constant Light Exposure Aggravates High Fat Diet-Induced Renal Injury In Rats, Lin Xing, Shanyu Wu, Ying Shi, Fangzhi Yue, Lin Wei, Ryan D. Russell, Dongmei Zhang
Health & Human Performance Faculty Publications and Presentations
Obesity-related kidney disease is now recognized as a global health issue, with a substantial number of patients developing progressive renal failure and end-stage renal disease. Interestingly, recent studies indicate light pollution is a novel environmental risk factor for chronic kidney disease. However, the impact of light pollution on obesity-related kidney disease remains largely unknown, with its underlying mechanism insufficiently explained. Renal hypoxia induced factor 1α (HIF1α) is critical in the development of glomerulosclerosis and renal fibrosis. The present study explored effects of constant light exposure on high fat diet (HFD) -induced renal injury and its association with HIF1α signal pathway. …
Impaired Postprandial Skeletal Muscle Vascular Responses To A Mixed Meal Challenge In Normoglycaemic People With A Parent With Type 2 Diabetes, Ryan D. Russell, Katherine M. Roberts-Thomson, Donghua Hu, Timothy Greenaway, Andrew C. Betik, Lewan Parker, James E. Sharman, Stephen M. Richards, Stephen Rattigan, Dino Premilovac, Glenn D. Wadley, Michelle A. Keske
Impaired Postprandial Skeletal Muscle Vascular Responses To A Mixed Meal Challenge In Normoglycaemic People With A Parent With Type 2 Diabetes, Ryan D. Russell, Katherine M. Roberts-Thomson, Donghua Hu, Timothy Greenaway, Andrew C. Betik, Lewan Parker, James E. Sharman, Stephen M. Richards, Stephen Rattigan, Dino Premilovac, Glenn D. Wadley, Michelle A. Keske
Health & Human Performance Faculty Publications and Presentations
Aims/hypothesis: Microvascular blood flow (MBF) increases in skeletal muscle postprandially to aid in glucose delivery and uptake in muscle. This vascular action is impaired in individuals who are obese or have type 2 diabetes. Whether MBF is impaired in normoglycaemic people at risk of type 2 diabetes is unknown. We aimed to determine whether apparently healthy people at risk of type 2 diabetes display impaired skeletal muscle microvascular responses to a mixed-nutrient meal.
Methods: In this cross-sectional study, participants with no family history of type 2 diabetes (FH-) for two generations (n = 18), participants with a positive family history …