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Full-Text Articles in Medicine and Health Sciences
Sensing Surfaces: A Non-Filamentous C. Albicans Response, Elias Smith
Sensing Surfaces: A Non-Filamentous C. Albicans Response, Elias Smith
Theses/Capstones/Creative Projects
Resulting infections of mucosal tissues by Candida albicans present difficulty in treatment due to the formation of biofilms and invasion of tissue directed by thigmo-tropic responses of hyphal cells. Initiation of biofilm formation, however, is largely dependent on yeast-form cells. Their ability to sense surfaces, however, has yet to be examined. In the present study, an initial genetic profiling of the surface sensing response by non-filamentous Candida albicans was generated. In order to assess the ability for yeast-form C. albicans cells to recognize surfaces, four differentially solidified YPD plate types were created using agar, noble agar, Gelrite, and carrageenan. Genetic …
Identification And Characterization Of Butyrate-Producing Species In The Human Gut Microbiome, Grace Maline
Identification And Characterization Of Butyrate-Producing Species In The Human Gut Microbiome, Grace Maline
Theses/Capstones/Creative Projects
Inflammatory Bowel Diseases (IBD) including ulcerative colitis, indeterminate colitis, and Crohn’s disease are increasingly common conditions that places a high physical and financial burden on individuals and global healthcare systems. Though many treatments exist for these conditions, their unpredictable nature and causation make them difficult to manage across the variety of IBD patients. Additionally, many of these treatments come with undesirable side effects or modes of delivery. Therefore, it is worthwhile to explore the use of Short Chain Fatty Acids (SCFAs) such as butyrate whose affects in the human gut include decreased inflammation and decreased risk of colorectal cancer. As …