Medicine and Health Sciences Commons^™

Molecular Detection Of Pathogenic Bacteria In American Dog Ticks (Dermacentor Variabilis) In Brown County, Nebraska, Nicole Messbarger, Darby Carlson, Keith Geluso, Julie Shaffer

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Ticks carry and transmit disease pathogens that cause many human illnesses. Many of these diseases in humans are accompanied by a wide variety of symptoms making tick-borne illnesses often difficult to diagnose. The rate of reported tick-borne illnesses in humans has increased during the past decades in the United States, alongside a rise in concern for public health and safety. In northern Nebraska, the American dog tick (Dermacentor variabilis) is the primary tick encountered by humans and domestic animals in the region. This species is a known vector for spotted fever group (SFG) rickettsioses and tularemia (Francisella …

Candida Albicans Farnesol Synthesis And Secretion, Daniel J. Gutzmann

School of Biological Sciences: Dissertations, Theses, and Student Research

Candida albicans is a polymorphic fungus and opportunistic commensal found primarily in the gastrointestinal and skin of healthy individuals. Several barriers prevent C. albicans from causing disease including a healthy immune system and microbiome. When these barriers become comprised, C. albicans can transition to a pathogen and disseminate through the intestinal mucosa leading to life-threatening bloodstream and invasive infections with mortality rates of up to 64%. Morphogenic plasticity is key to this transition and impacts virulence, adaptation to different host environments, and evasion of host immune responses. One regulator of morphogenesis is farnesol. Farnesol is a secondary metabolite …

Nanoparticle-Based Approaches To Brain Injury And Studies For Improved Detectability Toward Better Delivery Characterization, Hunter A. Miller

Dissertations and Doctoral Documents from University of Nebraska-Lincoln, 2023–

The clinical translation of nanoparticle (NP) therapeutics for brain injury has been slow despite preclinical promise. The causes of disconnect between preclinical and clinical outcomes is multifactorial, but insufficient delivery is noteworthy. Preclinical delivery characterization often lacks, obscuring mechanisms of failure, slowing development. Multimodal imaging is a promising strategy to improve delivery characterization, combining the strengths of various modalities. Magnetic resonance imaging (MRI) and luminescence imaging are a suitable combination for multimodal imaging, expanding the spatial and temporal resolution of either alone, but further material development is needed to enhance detectability. One problem is the interference of cellular autofluorescence in …

Development Of Feature Extraction Models To Improve Image Analysis Applications In Cancer, Yu Shi

Dissertations and Doctoral Documents from University of Nebraska-Lincoln, 2023–

Cancer poses a significant global health challenge. With an estimated 20 million new cases diagnosed worldwide in 2022 and 9.7 million fatalities attributable to the disease, the economic burden of cancer is immense. It impacts healthcare systems and imposes substantial costs for its care on patients and their families. Despite advancements in early detection, prevention, and treatment that have reduced overall cancer mortality rates, the growing prevalence of cancer, particularly among younger individuals, remains a pressing issue.

Recent advancements in medical imaging technology have progressed significantly with the help of emerging computer vision and artificial intelligence (AI) technology. Despite these …

Triticale As A Source Of Resistance To Wheat Streak Mosaic Virus And Triticum Mosaic Virus, Marcos Winicius Goncalves De Souza

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV) present a great threat to wheat production in the Great Plains area of the United States due to the loss of photosynthetic area causing reductions in crop yields. Effective control of these viruses is limited to a few available strategies including controlling volunteer wheat and using currently identified resistant genes to both the vector and viruses. While effective, these genes show temperature sensitivity and yield drag, and evidence that the vectors and viruses can overcome them has been found. Thus, new methods of genetic resistance are urgently needed. Field observations …

Data-Driven Drug Repurposing For Immune System-Related Diseases, Sabyasachi Mohanty

Department of Biochemistry: Dissertations, Theses, and Student Research

In this research, we explore a data-driven approach for drug repurposing to enhance the immunomodulatory effect by integrating pattern-based search and genome-scale metabolic modeling. This research helps to find a solution to the preexisting problems of drug discovery which includes expenses and a high amount of time consumption. By leveraging the pre-existing data of the approved drugs to identify the major metabolic pathway changes, we can find new drugs with similar effects with less off-target effects.

The focus on the immune system modulating drugs is due to the high prevalence of immune system-involved diseases and the growing demand for effective …

Development Of A Durable And Low-Dose Universal Vaccine Against Swine Influenza A Virus, Erika Petro-Turnquist

Dissertations and Doctoral Documents from University of Nebraska-Lincoln, 2023–

Swine Influenza A Virus (IAV-S) imposes a significant burden on the pork industry and poses a great threat to public health due to its zoonotic potential. Susceptibility to human, avian, and swine influenza make pigs the ultimate mixing vessels for reassorted influenza A virus strains. Current vaccination strategies induce short-lived and strain-specific responses against IAV-S. Further, the substantial genetic diversity of IAV-S necessitates consistent revaccination and updating of commercial vaccines. Computational platforms have recently emerged as a promising strategy to develop new-age vaccines against infectious diseases in livestock animals. Here, we describe a computationally derived set of vaccine immunogens, called …

Concepts In Animal Parasitology: Master Bibliography, Sue Ann Gardner

Concepts in Animal Parasitology Textbook

Master bibliography for the open educational resource/open access textbook Concepts in Animal Parasitology, Scott L. Gardner and Sue Ann Gardner, editors, published by Zea Books, Lincoln, Nebraska, United States, 2024. This includes the references from literature cited and suggested supplemental reading.

The Sexual Trauma Of The Female Body: Violence Against Women In Contemporary Spanish And Latin American Cultures, Lara Armenteros Garrido

Dissertations and Doctoral Documents from University of Nebraska-Lincoln, 2023–

This dissertation focuses on the idea that women’s bodies have a sexual stigma attached to them as a consequence of different forms of heteropatriarcal violence inflicted on them. From violence in public spaces, such as street harassment or the sexual exploitation of women, to the intimacy of the relationship, like intimate partner violence or the orgasm gap, it becomes increasingly difficult for women to escape violence. Through the analysis of films, documentaries, narratives, and the testimonies of women from Spain and Latin America, I argue there is still a lack of adequate sexual and emotional knowledge to help complete agency …

A Comparative Analysis Of Hiv/Aids In France And The United States: Historical Context And Preventative Actions, Rebecca A. Liebsack

Honors Theses

The HIV/AIDS pandemic is the result of transmission of a zoonotic disease known as simian immunodeficiency virus. The pandemic has had profound social and economic consequences and continues to be present today. France and the United States’ response to the discovery of HIV will be compared and the impact that HIV/AIDS had on their countries and future responses. They had rather similar responses, however, the United States had a slower initial response compared to France. Both had similar takeaways such as aiming at improving prevention and utilizing tactics developed during the start of the pandemic like frequent testing and vaccines.

Sarcopenia And The Importance Of Resistance Training And Protein-Rich Diets For Prevention Of Muscle Loss In Older Adults: A Literature Review And Informational Pamphlet, Madison Steele

Honors Theses

The growing prevalence of sarcopenia among older adults as well as youths has prompted further research aimed at developing effective preventative measures and treatment plans. Sarcopenia is often thought to occur solely due to aging, but several other factors contribute to progressive muscle loss. Previous research studies have found an effect of physical activity and dietary protein levels on the risk of developing sarcopenia as well as its onset age. This study aims to review existing knowledge in the field to compile an extensive list of sarcopenia causes and methods of prevention. The main causes identified in this review are …

Digital Phobia: An Inquiry For Mapping The Unseen Dimension Of New Digital Anxiety, The ‘Digiphobia’, Amarjit Kumar Singh ,Library Assistant, Md. Arshad Ali , Professional Assistant, Dr. Pankaj Mathur, Deputy Librarian,

Library Philosophy and Practice (e-journal)

Background: As technology continues to advance, individuals' interactions with digital platforms have become integral to daily life. Amidst this technological evolution, a novel concern emerges—Digital Phobia, hereafter referred to as “Digiphobia.” This phenomenon, although not previously explored in scholarly literature, necessitates an in-depth investigation due to its potential impact on individuals' well-being. Our research employs a two-step methodology to investigate its existence, implications, and manifestations.

Introduction: This research paper introduces and proposes the term "Digiphobia" as a comprehensive conceptualization of anxiety arising from interactions with digital spaces, applications, and environments. The proliferation of digital technologies has led to the emergence …

Applying The Evidence: Taste Manipulation As A Dysphagia Management Strategy, Ross M. Westemeyer, Angela M. Dietsch, Rachel W. Mulheren

Department of Special Education and Communication Disorders: Faculty Publications

Purpose: This narrative review aims to summarize the evidence regarding taste manipulation as a dysphagia management strategy within the evidence-based practice framework, with a focus on clinical application for speech-language pathologists.

Method: First, we present background information on the physiology of taste and swallowing. A summary of research evidence on the effect of taste on swallowing is presented, followed by suggested methods for incorporating taste into swallowing evaluation and intervention. An overview of individual factors that can impact taste perception is provided. Finally, we discuss methods of clinical application and future directions for clinicians.

Conclusions: Although taste …

Concepts In Animal Parasitology, Chapter 02: Phylogenetic Systematics In Parasitology, Anindo Choudhury

Concepts in Animal Parasitology Textbook

Chapter 2 in Concepts in Animal Parasitology on phylogenetic systematics in parasitology by Anindo Choudhury. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap002

Concepts In Animal Parasitology, Chapter 05: Life Cycles, Matthew G. Bolek, Kyle D. Gustafson, Gabriel J. Langford

Concepts in Animal Parasitology Textbook

Chapter 5 in Concepts in Animal Parasitology on life cycles by Matthew G. Bolek, Kyle D. Gustafson, and Gabriel J. Langford. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap005

Concepts In Animal Parasitology, Chapter 06: Behavioral Parasitology, Megan Wise De Valdez

Concepts in Animal Parasitology Textbook

Chapter 6 in Concepts in Animal Parasitology on behavioral parasitology by Megan Wise de Valdez. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap006

Concepts In Animal Parasitology, Chapter 08: Distributional Ecology Of Parasites, A. Townsend Peterson

Concepts in Animal Parasitology Textbook

Chapter 8 in Concepts in Animal Parasitology on distributional ecology of parasites by A. Townsend Peterson. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap008

Concepts In Animal Parasitology, Chapter 10: Haemosporida (Order): The “Malaria Parasites”, Susan L. Perkins, Spencer C. Galen

Concepts in Animal Parasitology Textbook

Chapter 10 in Concepts in Animal Parasitology on the order Haemosporida, the “malaria parasites,” by Susan L. Perkins and Spencer C. Galen. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap010

Concepts In Animal Parasitology, Chapter 24: Cathetocephalidea Schmidt And Beveridge, 1990 (Order), Luis García-Prieto, Omar Lagunas-Calvo, Brenda Atziri García-García, Berenice Adán-Torres

Concepts in Animal Parasitology Textbook

Chapter 24 in Concepts in Animal Parasitology on the order Cathetocephalidea Schmidt and Beveridge, 1990 by Luis García-Prieto, Omar Lagunas-Calvo, Brenda Atziri García-García, and Berenice Adán-Torres. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap024

Concepts In Animal Parasitology, Chapter 32: Gyrocotylidea (Order): The Most Primitive Group Of Tapeworms, Willi E. R. Xylander, Klaus Rohde

Concepts in Animal Parasitology Textbook

Chapter 32 in Concepts in Animal Parasitology on the most primitive group of tapeworms, the order Gyrocotylidea by Willi E. R. Xylander and Klaus Rohde. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap032

Concepts In Animal Parasitology, Chapter 37: Bivesiculata Olson Et Al., 2003 (Suborder): Small, Rare, But Important, Thomas H. Cribb, Scott C. Cutmore

Concepts in Animal Parasitology Textbook

Chapter 37 in Concepts in Animal Parasitology on the small, rare, but important suborder Bivesiculata Olson et al., 2003 by Thomas H. Cribb and Scott C. Cutmore. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap037

Concepts In Animal Parasitology, Chapter 42: Opisthorchis (Genus), Sue Ann Gardner

Concepts in Animal Parasitology Textbook

Chapter 42 in Concepts in Animal Parasitology on the trematode genus Opisthorchis compiled by Sue Ann Gardner from information from the United States Centers for Disease Control and Prevention, Division of Parasitic Diseases and Malaria. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap042

Concepts In Animal Parasitology, Chapter 44: Haematoloechidae Odening, 1964 (Family), Virginia León-Règagnon

Concepts in Animal Parasitology Textbook

Chapter 44 in Concepts in Animal Parasitology on the family Haematoloechidae Odening, 1964 by Virginia León-Règagnon. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap044

Concepts In Animal Parasitology, Chapter 45: Lecithodendriidae Lühe, 1901 (Family), Jeffrey M. Lotz

Concepts in Animal Parasitology Textbook

Chapter 45 in Concepts in Animal Parasitology on the family Lecithodendriidae Lühe, 1901 by Jeffrey M. Lotz. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap045

Concepts In Animal Parasitology, Chapter 48: Introduction To Endoparasitic Nematodes (Phylum Nemata), Scott L. Gardner

Concepts in Animal Parasitology Textbook

Chapter 48 in Concepts in Animal Parasitology, an introduction to endoparasitic nematodes (phylum Nemata) by Scott L. Gardner. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap048

Concepts In Animal Parasitology, Chapter 53: Spirurida (Order), Valentin Radev

Concepts in Animal Parasitology Textbook

Chapter 53 in Concepts in Animal Parasitology on the order Spirurida by Valentin Radev. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap053

Concepts In Animal Parasitology, Chapter 57: Nematomorpha (Phylum): Horsehair Worms, Matthew G. Bolek, Ben Hanelt

Concepts in Animal Parasitology Textbook

Chapter 57 in Concepts in Animal Parasitology on the horsehair worms, phylum Nematomorpha, by Matthew G. Bolek and Ben Hanelt. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap057

Concepts In Animal Parasitology, Chapter 59: Pentastomida: Endoparasitic Arthopods, Chris T. Mcallister

Concepts in Animal Parasitology Textbook

Chapter 59 in Concepts in Animal Parasitology on the Pentastomida, endoparasitic athropods, by Chris T. McAllister. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap059

Concepts In Animal Parasitology, Chapter 66: Acari (Order): Ticks, Darci Moraes Barros-Battesti, Valeria Castilho Onofrio, Filipe Dantas-Torres

Concepts in Animal Parasitology Textbook

Chapter 66 in Concepts in Animal Parasitology on ticks (order Acari) by Darci Moraes Barros-Battesti, Valeria Castilho Onofrio, and Filipe Dantas-Torres. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap066

Concepts In Animal Parasitology, Part 2: Protozoa, Myxozoa, Mesozoa, Donald W. Duszynski, Susan L. Perkins, Spencer C. Galen, Ana Maria Jansen, Samanta C. Chagas Xavier, André Luiz Rodrigues Roque, Mary Ann Mcdowell, Jennifer Robichaud, Terrence L. Miller, Sarah R. Catalano

Concepts in Animal Parasitology Textbook

Part II: Protozoa, Myxozoa, Mesozoa, chapters 9-14, pages 105-141, in Concepts in Animal Parasitology. 2024. Scott L. Gardner and Sue Ann Gardner, editors. Zea Books, Lincoln, Nebraska, United States; part II doi: 10.32873/unl.dc.ciap072

Protozoa: Apicomplexa

Chapter 9: The Coccidia Proper: Important Apicomplexa Other than Haemoprotozoa by Donald W. Duszynski, pages 105-139

Chapter 10: Haemosporida (Order): The “Malaria Parasites” by Susan L. Perkins and Spencer C. Galen, pages 140-155

Protozoa: Trypanosomatidae

Chapter 11: Trypanosoma (Genus) by Ana Maria Jansen, Samanta C. Chagas Xavier, and André Luiz Rodrigues Roque, pages 156-181

Chapter 12: Leishmania (Genus) and Leishmaniasis by Mary Ann McDowell and …