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Serine And Glutathione Biosynthesis In Breast Cancer Subclones That Preferentially Metastasize To Lung And Bone, Noah Thornton

Honors Theses

Metastatic breast cancers show distinct preferences to metastasize to lung and bone tissue. Transcriptomic analysis of lung-specific (LM) and bone-specific (BoM) subclones derived from the MDA-231 breast cancer line have identified differential expression of genes that may mediate this tissue-specific metastasis, but metabolic differences have not been systematically studied. If common metabolic phenotypes emerge in metastatic cancers having preferences for different organs, then such ‘metabolic plasticity’ may offer new therapeutic targets for treatment of specific metastases. Changes in glutathione (GSH) and serine synthesis may contribute to tissue-specific proliferation because of their roles in redox homeostasis, biosynthetic reactions including nucleotide synthesis, …