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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Impacts Of Dietary Restriction On A Drosophila Model Of Werner Syndrome, Eileen Sember
Impacts Of Dietary Restriction On A Drosophila Model Of Werner Syndrome, Eileen Sember
College of Arts & Sciences Senior Honors Theses
Werner syndrome (WS) is an autosomal recessive disorder that results in premature aging and occurs in 1 in 1,000,0000 to 1 in 10,000,000 people. In humans, WS is the result of mutations that render the WRN gene, that contains a helicase and an exonuclease domain, non-functional. Currently, there is no cure for WS in humans, making dietary and lifestyle interventions attractive for increasing the quality and longevity of lives. Diet restriction (DR) has been shown to extend the lifespan of several model organisms, including Drosophila melanogaster, making it a strong candidate for WS treatment. In this thesis, mutant flies …
An Evaluation Of Covid-19 Vaccination Rates Of The Patients At The Kentucky Racing Health Services Center., Aditya Mehta
An Evaluation Of Covid-19 Vaccination Rates Of The Patients At The Kentucky Racing Health Services Center., Aditya Mehta
College of Arts & Sciences Senior Honors Theses
COVID-19 vaccines have been widely available to the U.S. public since early 2021. However, vaccination rates still vary considerably across geographical areas and different populations. The objective of this study was to research overall vaccination rates against COVID-19 for Latinx patients at the Kentucky Racing Health Services Center (KRHSC). Vaccination and booster data was collected from June to December 2021 for all unique patients visiting the center. It was initially hypothesized that these rates of vaccination and booster doses for the KRHSC patients would be lower than the data reported by Kentucky and Jefferson County. After a retrospective review, the …
Filifactor Alocis: Resilience And Manipulation Against Neutrophil Effector Functions In A Dysbiotic Oral Environment., Max N. Rogers
Filifactor Alocis: Resilience And Manipulation Against Neutrophil Effector Functions In A Dysbiotic Oral Environment., Max N. Rogers
College of Arts & Sciences Senior Honors Theses
Periodontitis is a multifactorial chronic inflammatory infectious disease that affects around 50% of the adult population in the USA. Neutrophils, which are the primary immune cells recruited to restore health at sites of infection, are profuse in the gingival space during oral infections. In a community-wide effort, pathogenic oral bacteria hijack neutrophil effector functions to evade killing, resulting in an uncontrollable inflammatory loop that leads into inflammation-mediated tissue injury. One of these harmful emerging oral pathogens, Filifactor alocis, has been shown to evade neutrophil killing and contribute to disease progression. The purpose of this study is to gain a …
The Effect Of Interspecies Signaling On Stenotrophomonas Maltophilia Growth., Zachary Ethan Dickinson
The Effect Of Interspecies Signaling On Stenotrophomonas Maltophilia Growth., Zachary Ethan Dickinson
College of Arts & Sciences Senior Honors Theses
Cystic fibrosis (CF) is a genetic disorder that effects over 70,000 people worldwide, and is particularly prevalent in those of Caucasian descent. CF increases susceptibility to chronic infections of the lungs and GI tract, often leading to decreased quality of life and early death to afflicted individuals. No cure is available, and so treatment is limited to treating the frequent infections that afflict CF patients. Several species of bacteria are commonly implicated in these infections, including Stenotrophomonas maltophilia. Infections of this species is of particular interest as it has been shown to be highly antibiotic resistant. This is a concern …
Public Health Department Perspectives On Cervical And Prostate Cancer Prevention In Southeastern Kentucky., Jordan Danielle Burns
Public Health Department Perspectives On Cervical And Prostate Cancer Prevention In Southeastern Kentucky., Jordan Danielle Burns
College of Arts & Sciences Senior Honors Theses
This study compared and contrasted the screening and prevention methods and strategies utilized by public health departments in southeastern Kentucky for both cervical and prostate cancer. Special attention was paid to how such efforts have influenced decreases in mortality rates over the past two decades. The study used both geospatial methods, such as Exploratory Spatial Data Analysis (ESDA) and spatial autocorrelation, and qualitative methods in form of interviews. The interview data showed that Kentucky public health departments had strong cervical cancer screening and prevention programs, but did not focus on prostate cancer prevention. Successes in cervical cancer screening included the …