Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Epidemiology (2)
- Simulation (2)
- 4-Aryl-4H-chromene (1)
- Agent-Based (1)
- Agent-based model (1)
-
- Anti-proliferative (1)
- Benzopyran Anticancer (1)
- Breast cancer (1)
- COVID-19 (1)
- COVID-19 pandemic (1)
- Centrality (1)
- Cytotoxic (1)
- Equation Based (1)
- Estrogen receptor alpha (1)
- Estrogen receptor beta (1)
- Europe (1)
- Flattening the curve (1)
- Hybrid (1)
- Infectious Disease (1)
- Infectious disease (1)
- Isoform selectivity (1)
- Knovenagel condensation (1)
- Medicalization (1)
- Modelling (1)
- Molecular modeling (1)
- Pilgrimage (1)
- Religious travel (1)
- SARS-CoV-2 (1)
- Schools (1)
- Smoking (1)
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
The Covid-19 Pandemic And Religious Travel: Present And Future Trends, Daniel H. Olsen, Dallen Timothy
The Covid-19 Pandemic And Religious Travel: Present And Future Trends, Daniel H. Olsen, Dallen Timothy
International Journal of Religious Tourism and Pilgrimage
The COVID-19 pandemic of 2020 has had dramatic effects on both the health and economic stability of countries around the world. While several scholars and media commentators have suggested that the pandemic would be a good time to reset an unsustainable tourism system, left out of these discussions has been the impacts on religion and religious travel. The purpose of this paper is to review the impacts of the COVID-19 pandemic on religion and religious travel, including the tensions that have arisen between religious communities, governments and health officials. The paper then discusses potential futures regarding religious travel in a …
A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher
A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher
Articles
Both agent-based models and equation-based models can be used to model the spread of an infectious disease. Equation-based models have been shown to capture the overall dynamics of a disease outbreak while agent-based models are able to capture heterogeneous characteristics of agents that drive the spread of an outbreak. However, agent-based models are computationally intensive. To capture the advantages of both the equation-based and agent-based models, we create a hybrid model where the disease component of the hybrid model switches between agent-based and equation-based. The switch is determined using the number of agents infected. We first test the model at …
A Model For The Spread Of Infectious Diseases In A Region, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher
A Model For The Spread Of Infectious Diseases In A Region, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher
Articles
In understanding the dynamics of the spread of an infectious disease, it is important to understand how a town’s place in a network of towns within a region will impact how the disease spreads to that town and from that town. In this article, we take a model for the spread of an infectious disease in a single town and scale it up to simulate a region containing multiple towns. The model is validated by looking at how adding additional towns and commuters influences the outbreak in a single town. We then look at how the centrality of a town …
Espad Report 2019: Results From European School Survey Project On Alcohol And Other Drugs, Sabrina Mokinaro, Julian Vincente, Elisa Benedetti, Sonia Cerrai, Emanuala Colasante, Sharon Arpa, Pavla Chomynova, Ludwig Kraus, Karin Monshouwer, Stanislas Spika, Arsaell Mar Arnarsson, Olga Balakireva, Begona Brime Beteta, Elin Kristin Bye, Anina Chileva, Luke Clancy, Zamira Hyseni Duraku, Tatijana Durisic, Olga Ekholm, Zsuzsanna Elekes, Silvia Florescu, Biljana Kilibarda, Anna Kokkevi, Elsa Lavado, Tanja Urdih Lazar, Martina Markelic, Alojz Nociar, Silvana Oncheva, Kirsimarja Raitasalo, Ludmilla Rupsience, Janusz Sieroslawski, Julian Strizek, Lela Sturua, Johan Svensson, Diana Vanaga, Kyriakos Veresies, Sigrid Vorobjov, Pai Weihe, Rodolfo Cotichini, Loredana Fortunato, Katenna Skarupova
Espad Report 2019: Results From European School Survey Project On Alcohol And Other Drugs, Sabrina Mokinaro, Julian Vincente, Elisa Benedetti, Sonia Cerrai, Emanuala Colasante, Sharon Arpa, Pavla Chomynova, Ludwig Kraus, Karin Monshouwer, Stanislas Spika, Arsaell Mar Arnarsson, Olga Balakireva, Begona Brime Beteta, Elin Kristin Bye, Anina Chileva, Luke Clancy, Zamira Hyseni Duraku, Tatijana Durisic, Olga Ekholm, Zsuzsanna Elekes, Silvia Florescu, Biljana Kilibarda, Anna Kokkevi, Elsa Lavado, Tanja Urdih Lazar, Martina Markelic, Alojz Nociar, Silvana Oncheva, Kirsimarja Raitasalo, Ludmilla Rupsience, Janusz Sieroslawski, Julian Strizek, Lela Sturua, Johan Svensson, Diana Vanaga, Kyriakos Veresies, Sigrid Vorobjov, Pai Weihe, Rodolfo Cotichini, Loredana Fortunato, Katenna Skarupova
Reports
The main purpose of the European School Survey Project on Alcohol and Other Drugs (ESPAD) is to collect comparable data on substance use and other forms of risk behaviour among 15- to 16-year-old students in order to monitor trends within, as well as between, countries. Between 1995 and 2019, seven waves of data collection were conducted across 49 European countries. This report presents selected key results. The full set of data on which the current report is based, including all of the standard tables, is available online (http://www.espad.org). All tables can be downloaded in Excel format and used for further …
Covid-19: A Simple Curve Approximation Tool, Jane Courtney
Covid-19: A Simple Curve Approximation Tool, Jane Courtney
Articles
In the current COVID-19 pandemic, much focus is put on ‘flattening the curve’. This ‘curve’ refers to the cases versus time graph, which shows the rise of a disease to its peak before descending. The aim in a pandemic is to flatten this curve by reducing the peak and spreading out the timeline. However, the models used to predict this curve are often not clearly outlined, no model parameters are given, and models are not tested against real data. This lack of detail makes it difficult to recreate the curve from these models. What is much needed is a simple …
Optimisation Of Estrogen Receptor Subtype-Selectivity Of A 4-Aryl-4h-Chromene Scaffold Previously Identified By Virtual Screening, Miriam Carr, Andrew Knox, Daniel Nevin, Niamh O'Boyle, Shu Wang, Billy Egan, Thomas Mccabe, Brendan Twamley, Daniela Zisterer, David Lloyd, Mary Meegan
Optimisation Of Estrogen Receptor Subtype-Selectivity Of A 4-Aryl-4h-Chromene Scaffold Previously Identified By Virtual Screening, Miriam Carr, Andrew Knox, Daniel Nevin, Niamh O'Boyle, Shu Wang, Billy Egan, Thomas Mccabe, Brendan Twamley, Daniela Zisterer, David Lloyd, Mary Meegan
Articles
4-Aryl-4H-Chromene derivatives have been previously shown to exhibit anti-proliferative, apoptotic and anti-angiogenic activity in a variety of tumor models in vitro and in vivo generally via activation of caspases through inhibition of tubulin polymerisation. We have previously identified by Virtual Screening (VS) a 4-aryl-4H-chromene scaffold, of which two examples were shown to bind Estrogen Receptor α and β with low nanomolar affinity and <20-fold selectivity for α over β and low micromolar anti-proliferative activity in the MCF-7 cell line. Thus, using the 4-aryl-4H-chromene scaffold as a starting point, a series of compounds with a range of basic arylethers at C-4 and modifications at the C3-ester substituent of the benzopyran ring were synthesised, producing some potent ER antagonists in the MCF-7 cell line which were highly selective for ERα (compound 35; 350-fold selectivity) or ERβ (compound 42; 170-fold selectivity).