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Full-Text Articles in Medicine and Health Sciences
Why New Diseases Keep Popping Up, Alan L. Gillen, Jason Conrad
Why New Diseases Keep Popping Up, Alan L. Gillen, Jason Conrad
Faculty Publications and Presentations
New and reemerging diseases are terrifying and concerning problems. Not only do they carry a financial and emotional toll, but they account for significant numbers of death. Emerging diseases are usually zoonotic and highly virulent in nature. These are pathogenic and parasitic diseases of high consequence and impact. Why would a good Creator allow these new diseases? Why do new diseases keep popping up? Mutation and displacement of original types of microbes account for many new diseases; however, the answer is more complex than just these two factors. Zoonoses are the most common type of infection, specifically from viral pathogens, …
The Theory Of Maternal Administration Of Meclizine: An Achondroplasic Review And The Proposed Treatment Of Foramen Magnum Stenosis Within A Murine Model, Ava Perez Erickson
The Theory Of Maternal Administration Of Meclizine: An Achondroplasic Review And The Proposed Treatment Of Foramen Magnum Stenosis Within A Murine Model, Ava Perez Erickson
Senior Honors Theses
Arising from mostly de novo mutations, achondroplasia (ACH) is one of the most common, non-lethal forms of chondrodysplasia. The short stature indicative of ACH stems from a gain of function mutation within the complex FGFR3 signaling pathway—mutations mitigating the too-rapid ossification of cartilage to bone. Meclizine, an FDA-approved drug long prescribed for motion sickness, halts such a conversion and allows the reconstitution of chondrodysplasia cell lines in attempts at following a normal growth pattern. Evinced by various cell line rescues as well as increased long bone growth, it can be hypothesized that maternally administered meclizine can rescue the ACH phenotype …