Medicine and Health Sciences Commons^™

Epidermal Growth Factor Receptor In Joint Health And Osteoarthritis, Michael A. Pest

Electronic Thesis and Dissertation Repository

Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases in the world. Our laboratory has shown that epidermal growth factor receptor (EGFR) signalling is involved in the process of cartilage degeneration in OA. Regulation of EGFR signalling by mitogen-inducible gene 6 (Mig-6) and dual specificity phosphatase 1 (DUSP-1) allows for signal modulation, and mouse models have linked these proteins to joint pathologies. Failure to control EGFR signalling may be involved in OA progression leading to my overarching hypothesis: regulation of EGFR signalling is essential for maintenance of joint health.

I initially tested the role of Mig-6 in cartilage health …

Is Ayurvedic Effective In Reducing Osteoarthritis Pain In Adults?, Reja Khan

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not Ayurvedic is effective in reducing osteoarthritis pain in adults.

Study Design: Review of three English language randomized controlled trials published between from 2004-2013.

Data Sources: Two double blind randomized controlled trials and one open label randomized controlled clinical trial were found using PubMed and Cochrane Library databases.

Outcomes Measured: To measure the effectiveness, the following parameters were utilized visual analog scale (VAS) reported by the patient to assess reduction in pain symptoms of osteoarthritis.

Results: Three randomized controlled studies results found that Ayurvedic medicine was beneficial …

Is Ginger Effective In Reducing Knee Pain In Adults With Osteoarthritis?, Joseph Heng

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this evidence based medicine review is to determine whether ginger is effective in reducing knee pain in adults with osteoarthritis.

Study Design: Three double blind, randomized controlled trials were reviewed and selected based on their relevance to the clinical question and their inclusion of patient oriented outcomes (POEMS).

Data Sources: Each study was obtained by searching Cochrane and PubMed database.

Outcomes Measured: The outcomes were measured using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) via Likert scale and Knee Pain rated via Knee injury and knee Osteoarthritis Outcome score (KOOS) questionnaire which is a …