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Full-Text Articles in Medicine and Health Sciences
Distinct Hyperuricemia Trajectories Are Associated With Different Risks Of Incident Diabetes: A Prospective Cohort Study, Jia Liu, Huiying Pan, Yue Liu, Mengying Guan, Xia Li, Shuo Chen, Xingyao Tong, Yanxia Luo, Xiaonan Wang, Xinghua Yang, Xiuhua Guo, Jingbo Zhang, Lixin Tao
Distinct Hyperuricemia Trajectories Are Associated With Different Risks Of Incident Diabetes: A Prospective Cohort Study, Jia Liu, Huiying Pan, Yue Liu, Mengying Guan, Xia Li, Shuo Chen, Xingyao Tong, Yanxia Luo, Xiaonan Wang, Xinghua Yang, Xiuhua Guo, Jingbo Zhang, Lixin Tao
Research outputs 2022 to 2026
Background and aim: Conflicting results suggest a link between serum uric acid and diabetes and previous studies ignored the effect of continuous exposure of serum uric acid on diabetes risk. This study aims to characterize hyperuricemia trajectories in middle-aged adults and to examine its potential impact on diabetes risk, considering the role of obesity, dyslipidemia, and hypertension. Methods and results: The cohort included 9192 participants who were free of diabetes before 2013. The hyperuricemia trajectories during 2009–2013 were identified by latent class growth models. Incident diabetes during 2014–2018 was used as the outcome. Modified Poisson regression models were used to …
A Mild Causal Relationship Between Tea Consumption And Obesity In General Population: A Two-Sample Mendelian Randomization Study, Cancan Li, Mingyun Niu, Zheng Guo, Pengcheng Liu, Yulu Zheng, Di Liu, Song Yang, Wei Wang, Yuanmin Li, Haifeng Hou
A Mild Causal Relationship Between Tea Consumption And Obesity In General Population: A Two-Sample Mendelian Randomization Study, Cancan Li, Mingyun Niu, Zheng Guo, Pengcheng Liu, Yulu Zheng, Di Liu, Song Yang, Wei Wang, Yuanmin Li, Haifeng Hou
Research outputs 2022 to 2026
Evidence from observational studies for the effect of tea consumption on obesity is inconclusive. This study aimed to verify the causal association between tea consumption and obesity through a two-sample Mendelian randomization (MR) analysis in general population-based datasets. The genetic instruments, single nucleotide polymorphisms (SNPs) associated with tea consumption habits, were obtained from genome-wide association studies (GWAS): UK Biobank, Nurses’ Health Study, Health Professionals Follow-up Study, and Women’s Genome Health Study. The effect of the genetic instruments on obesity was analyzed using the UK Biobank dataset (among ∼500,000 participants). The causal relationship between tea consumption and obesity was analyzed by …