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Full-Text Articles in Medicine and Health Sciences
Validation Of A Serotonin Checklist In A Parkinson’S Disease Population, Kelly Diane Darby-Holder
Validation Of A Serotonin Checklist In A Parkinson’S Disease Population, Kelly Diane Darby-Holder
Loma Linda University Electronic Theses, Dissertations & Projects
Although the distinctive pathological marker of Parkinson’s Disease is the progressive death of neurons that produce dopamine, there are also alterations in the production of quantities of other neurotransmitters, such as norepinephrine and serotonin that contribute to the disease. Parkinson’s Disease (PD) can be divided into two distinct classes based on the manifestation of motor symptoms, Type A and Type B Parkinson’s Disease. Type B PD patients often manifest symptoms in which serotonin deficiency plays an important role, which often includes a history of depression. Within the brain and spinal cord serotonin has wide spread projections, acting as an important …
Multiple Psychosocial Factors As Predictors In The Progression Of Hiv-1 To Aids, Robert Louis Dutile
Multiple Psychosocial Factors As Predictors In The Progression Of Hiv-1 To Aids, Robert Louis Dutile
Loma Linda University Electronic Theses, Dissertations & Projects
Nearly 3.1 million individuals have died of AIDS as of December 2002 and more than 38.6 million individuals were identified as being infected with HIV (Joint United Nations Programme on HIV/AEDS (UNAIDS) and World Health Organization (WHO) 2002). Psychoneuroimmunology is a discipline that increases our understanding of the relationships between psychosocial factors, the central nervous system, the immune system, and disease. From this perspective, this study reviews the biopsychosocial medical model and components of the stress-immunity-health (SET) model. The constructs of stress and social support are discussed and defined referencing current theory and research. In addition, physiological mechanisms of stress …
Potential Mechanisms Explaining The Antitumor Effect Of Total-Body Irradiation, Glen Michael Miller
Potential Mechanisms Explaining The Antitumor Effect Of Total-Body Irradiation, Glen Michael Miller
Loma Linda University Electronic Theses, Dissertations & Projects
While numerous reports have documented that radiation exposure increases the risk for malignancy and suppresses immune mechanisms, increasing evidence has suggested that low-dose total-body irradiation (TBI) may alter leukocyte composition and function leading to heightened immune responsiveness and long-term remission of certain cancers. Having observed that moderate-dose TBI produces an antitumor effect in the Lewis lung carcinoma (EEC) model, the major goal of this study was to determine whether changes in tumor growth could be correlated with radiation-induced alterations of immune system parameters. The governing hypothesis was that selective immune augmentation, i.e. upregulation of specific leukocyte subsets, is primarily responsible …