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Labeling Of Retinal Ganglion Cells In A Rat Glaucoma Model, Lucia Rodriguez
Labeling Of Retinal Ganglion Cells In A Rat Glaucoma Model, Lucia Rodriguez
Honors Theses
Glaucoma is a degenerative disease of the retina containing multifactorial structural and functional defects. There is a loss of retinal ganglion cells (RGCs) seen in this optic disorder. Cupping of the optic disk seen in glaucoma is a result of the loss of RGC axons at the optic nerve head where the nerve fibers connect. As a result of these factors, visual field loss is common among glaucoma patients.1 In the United States, this visual field loss associated with glaucoma is one of the leading causes of blindness since glaucoma is difficult to detect.2 Usually, increased intraocular pressure …
Vaccinia Virus Flll Mediated Expedition Of Tanapoxvirus Replication In Cell Culture, Yih Wen Goh
Vaccinia Virus Flll Mediated Expedition Of Tanapoxvirus Replication In Cell Culture, Yih Wen Goh
Masters Theses
Tanapoxvirus (TPV) produces large but slow-forming plaques as opposed to vaccinia virus (VACV) that forms similar large plaques but more rapidly. A number of genes were identified in VACV, inclucding FllL, A33R, A34R and A36R that contribute to the regulation of virus release and dissemination, and are particularly responsible for the induction of actin tails. Among them, TPV lacks homologs of the FllL and A36R genes. F11Lmediated inhibition of RhoA-mDia signaling was shown to enhance the microtubules dynamics and modulates the cortical actin that assisted in the release of progeny virus from infected cells. To understand the possible effects of …