Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
The Medical Response To The Black Death, Joseph A. Legan
The Medical Response To The Black Death, Joseph A. Legan
Senior Honors Projects, 2010-2019
This paper discusses the medical response to the Black Death in both Europe and the Middle East. The Black Death was caused by a series of bacterial strands collectively known as Yersinia pestis. The Plague originated in the Mongolian Steppes. It was spread westward by the east-west trading system. Once it arrived in the Crimea in 1346, Italian merchants helped spread it throughout the Mediterranean. Medicine in Europe and the Middle East were centered on Galen’s theory of humors. There were many religious explanations for the Plague, but the main medical explanation was the spread of bad air, or …
Structural Studies Of The Ig58 Domain Of The Giant Muscle Protein Obscurin, Matthew C. Oehler
Structural Studies Of The Ig58 Domain Of The Giant Muscle Protein Obscurin, Matthew C. Oehler
Senior Honors Projects, 2010-2019
Obscurin (720-900 kD) is a giant sarcomeric signaling protein that is the only known link
between the cytoskeleton and the surrounding membrane structure. Mutations to obscurin
and to obscurin binding partners have been linked to human muscle diseases such as
hypertrophic cardiomyopathies and muscular dystrophy. These diseases likely occur due
to the abrogation of specific molecular interactions necessary for suitable function. To
more fully understand how specific mutations lead to disease, here we solve the highresolution
structure of obscurin Ig58. The literature shows that an Arg8Gln mutation to
the Ig58 domain of obscurin is associated with hypertrophic cardiomyopathy (HCM).
Chemical …
The Effect Of Run Sprint Interval Training On Diabetic Metabolic Markers In Prediabetic Adults, Kathryn L. Hilovsky
The Effect Of Run Sprint Interval Training On Diabetic Metabolic Markers In Prediabetic Adults, Kathryn L. Hilovsky
Masters Theses, 2010-2019
Abstract
Purpose: The primary purpose of this study was to compare the effects of an 8-week run-sprint interval training (R-SIT) and continuous moderate-intensity training (MIT) on fasting blood glucose, HbA1c, insulin sensitivity, and β-cell function in sedentary, prediabetic adults. Secondary outcomes of the study included anthropometric, body composition variables, and aerobic capacity.
Methods: Sedentary, physician diagnosed prediabetic individuals were randomized into R-SIT (n=7, BMI 36.76 ± 9.79) or MIT (n=8, BMI 40.59 ± 12.49) interventions. Subjects participated in supervised exercise three times a week and attended a Diabetes Prevention Program course, once weekly. R-SIT participants performed 4-6 x 30-second …