Medicine and Health Sciences Commons^™

Distinct Hyperuricemia Trajectories Are Associated With Different Risks Of Incident Diabetes: A Prospective Cohort Study, Jia Liu, Huiying Pan, Yue Liu, Mengying Guan, Xia Li, Shuo Chen, Xingyao Tong, Yanxia Luo, Xiaonan Wang, Xinghua Yang, Xiuhua Guo, Jingbo Zhang, Lixin Tao

Research outputs 2022 to 2026

Background and aim: Conflicting results suggest a link between serum uric acid and diabetes and previous studies ignored the effect of continuous exposure of serum uric acid on diabetes risk. This study aims to characterize hyperuricemia trajectories in middle-aged adults and to examine its potential impact on diabetes risk, considering the role of obesity, dyslipidemia, and hypertension. Methods and results: The cohort included 9192 participants who were free of diabetes before 2013. The hyperuricemia trajectories during 2009–2013 were identified by latent class growth models. Incident diabetes during 2014–2018 was used as the outcome. Modified Poisson regression models were used to …

A Mild Causal Relationship Between Tea Consumption And Obesity In General Population: A Two-Sample Mendelian Randomization Study, Cancan Li, Mingyun Niu, Zheng Guo, Pengcheng Liu, Yulu Zheng, Di Liu, Song Yang, Wei Wang, Yuanmin Li, Haifeng Hou

Research outputs 2022 to 2026

Evidence from observational studies for the effect of tea consumption on obesity is inconclusive. This study aimed to verify the causal association between tea consumption and obesity through a two-sample Mendelian randomization (MR) analysis in general population-based datasets. The genetic instruments, single nucleotide polymorphisms (SNPs) associated with tea consumption habits, were obtained from genome-wide association studies (GWAS): UK Biobank, Nurses’ Health Study, Health Professionals Follow-up Study, and Women’s Genome Health Study. The effect of the genetic instruments on obesity was analyzed using the UK Biobank dataset (among ∼500,000 participants). The causal relationship between tea consumption and obesity was analyzed by …

Higher Habitual Flavonoid Intakes Are Associated With A Lower Incidence Of Diabetes, Nicola P. Bondonno, Frederik Dalgaard, Kevin Murray, Raymond J. Davey, Catherine P. Bondonno, Aedin Cassidy, Joshua R. Lewis, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Jonathan M. Hodgson

Research outputs 2014 to 2021

Background:

Higher flavonoid intakes are hypothesized to confer protection against type 2 diabetes mellitus.

Objectives:

We aimed to 1) investigate associations between flavonoid intakes and diabetes, 2) examine the mediating impact of body fat, and 3) identify subpopulations that may receive the greatest benefit from higher flavonoid intakes in participants of the Danish Diet, Cancer, and Health Study followed up for 23 y.

Methods:

Cross-sectional associations between baseline flavonoid intake, estimated using FFQs and the Phenol Explorer database, and body fat, estimated by bioelectrical impedance, were assessed using multivariable-Adjusted linear regression models. Nonlinear associations between flavonoid intake and incident diabetes …

Diet And Nutrition Reverse Type 3 Diabetes And Accelerated Aging Linked To Global Chronic Diseases, Ian James Martins

Research outputs 2014 to 2021

The acceleration in the rate of chronic diseases that involve insulin resistance has become of global concern. The rate of the most prevalent chronic disease such as cardiovascular disease is linked to the metabolic syndrome, non alcoholic fatty liver disease (NAFLD) and other chronic diseases that include obesity, diabetes and neurodegenerative diseases. The gene-environment interaction in Western countries indicates that with urbanization access to food and its content may lead to induction of epigenetic alterations and identify the gene Sirtuin 1 (Sirt 1) to be responsible for the increased risk for insulin resistance and NAFLD relevant to Type 1, Type …

Lifestyle Factors, Medication Use And Risk For Ischaemic Heart Disease Hospitalisation: A Longitudinal Population-Based Study, Anthony S. Gunnell, K Einarsdottir, Daniel A. Galvao, S Joyce, S Tomlin, Vicki J. Graham, Caroline Mcintyre, Robert U. Newton, T Briffa

Research outputs 2013

Background:Lifestyle factors have been implicated in ischaemic heart disease (IHD) development however a limited number of longitudinal studies report results stratified by cardio-protective medication use.Purpose:This study investigated the influence of self-reported lifestyle factors on hospitalisation for IHD, stratified by blood pressure and/or lipid-lowering therapy.Methods:A population-based cohort of 14,890 participants aged 45+ years and IHD-free was identified from the Western Australian Health and wellbeing Surveillance System (2004 to 2010 inclusive), and linked with hospital administrative data. Adjusted hazard ratios for future IHD-hospitalisation were estimated using Cox regression.Results:Current smokers remained at higher risk for IHD-hospitalisation (adjusted HR=1.57; 95% CI: 1.22-2.03) after adjustment …