Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Apoptosis (1)
- Autoimmune Thyroiditis (1)
- Blue light (1)
- Blue light-induced damage (1)
- Experimental Autoimmune Thyroiditis (1)
-
- Eye health (1)
- Eyes (1)
- LEDs (1)
- MRNA (1)
- Mitochondria (1)
- Mitochondrial metabolism (1)
- Mitochondrial respiratory chain (1)
- NLRP3 Inflammasome (1)
- Near-infrared light (1)
- Oxidative phosphorylation (1)
- Oxidative stress (1)
- Photobiomodulation (1)
- Photoreceptors (1)
- Reactive oxygen species (1)
- Red light (1)
- Retina (1)
- Retinal cells (1)
- VDR (1)
- Vitamin D (1)
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
High Energy Blue Light Induces Oxidative Stress And Retinal Cell Apoptosis, Jessica Malinsky
High Energy Blue Light Induces Oxidative Stress And Retinal Cell Apoptosis, Jessica Malinsky
Capstone Showcase
Blue light (BL) is a high energy, short wavelength spanning 400 to 500 nm. Found in technological and environmental forms, BL has been shown to induce photochemical damage of the retina by reactive oxygen species (ROS) production. Excess ROS leads to oxidative stress, which disrupts retinal mitochondrial structure and function. As mitochondria amply occupy photoreceptors, they also contribute to oxidative stress due to their selectively significant absorption of BL at 400 to 500 nm. ROS generation that induces oxidative stress subsequently promotes retinal mitochondrial apoptosis. BL filtering and preventative mechanisms have been suggested to improve or repair BL-induced retinal damage, …
Vitamin D Enhanced Vitamin D Receptor (Vdr) Inhibition Of Nlrp3 Inflammasome Activation Can Attenuate The Development Of Autoimmune Thyroiditis, Alexzon Mandac
Vitamin D Enhanced Vitamin D Receptor (Vdr) Inhibition Of Nlrp3 Inflammasome Activation Can Attenuate The Development Of Autoimmune Thyroiditis, Alexzon Mandac
Capstone Showcase
Autoimmune Thyroiditis (AIT) is a prevalent autoimmune disease affecting approximately 2% of the population. Characterized by the gradual loss of thyroid function through an autoimmune attack on the thyroid gland, the disease manifests symptoms that negatively affect one’s quality of life. The mechanisms behind the disease’s pathophysiology are not fully understood; however, researchers are examining the involvement of the NLRP3 inflammasome in the disease. This thesis will address the question of whether Vitamin D can act as an inhibitor of the NLRP3 inflammasome and attenuate the progression of AIT in mouse model. Current investigations explore the effects of NLRP3 inhibition …