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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
Persistence Of Episomal Hiv-1 Infection Intermediates In Patients On Highly Active Anti-Retroviral Therapy, Mark Sharkey, Ian Teo, Thomas Greenough, Natalia Sharova, Katherine Luzuriaga, John Sullivan, R. Bucy, Leondios Kostrikis, Ashley Haase, Claire Veryard, Raul Davaro, Sarah Cheeseman, Jennifer Daly, Carol Bova, Richard Ellison, Brian Mady, Kwan Lai, Graeme Moyle, Mark Nelson, Brian Gazzard, Sunil Shaunak, Mario Stevenson
Persistence Of Episomal Hiv-1 Infection Intermediates In Patients On Highly Active Anti-Retroviral Therapy, Mark Sharkey, Ian Teo, Thomas Greenough, Natalia Sharova, Katherine Luzuriaga, John Sullivan, R. Bucy, Leondios Kostrikis, Ashley Haase, Claire Veryard, Raul Davaro, Sarah Cheeseman, Jennifer Daly, Carol Bova, Richard Ellison, Brian Mady, Kwan Lai, Graeme Moyle, Mark Nelson, Brian Gazzard, Sunil Shaunak, Mario Stevenson
Associate Professor Mark Nelson
Treatment of HIV-1-infected individuals with a combination of anti-retroviral agents results in sustained suppression of HIV-1 replication, as evidenced by a reduction in plasma viral RNA to levels below the limit of detection of available assays. However, even in patients whose plasma viral RNA levels have been suppressed to below detectable levels for up to 30 months, replication-competent virus can routinely be recovered from patient peripheral blood mononuclear cells and from semen. A reservoir of latently infected cells established early in infection may be involved in the maintenance of viral persistence despite highly active anti-retroviral therapy. However, whether virus replication …
Immunomodulators As Therapeutic Strategies For Managing Multiple Sclerosis, Ekua Brenu, Lotti Tajouri, Donald Staines, Sonya Marshall-Gradisnik
Immunomodulators As Therapeutic Strategies For Managing Multiple Sclerosis, Ekua Brenu, Lotti Tajouri, Donald Staines, Sonya Marshall-Gradisnik
Sonya Marshall-Gradisnik
Immunomodulation and immunosuppression are important strategies for monitoring autoimmune disorders. As imbalances in immune function affect other physiological processes, immunomodulators may have an important role in restoring and maintaining regular neuroimmue activities. In recent years these agents have demonstrated important benefits in controlling the mechanisms associated with deteriorating central nervous system pathologies such as Multiple Sclerosis (MS), where central and peripheral nervous system immune regulation is impaired. MS is characterized by severe compromises to neuroimmune processes involving changes in immune cell function, soluble proteins and modulation of inflammatory processes. The introduction of therapeutic agents in the form of immunomodulators; interferon, …
Immunomodulators As Therapeutic Strategies For Managing Multiple Sclerosis, Ekua Brenu, Lotti Tajouri, Donald Staines, Sonya Marshall-Gradisnik
Immunomodulators As Therapeutic Strategies For Managing Multiple Sclerosis, Ekua Brenu, Lotti Tajouri, Donald Staines, Sonya Marshall-Gradisnik
Lotti Tajouri
Immunomodulation and immunosuppression are important strategies for monitoring autoimmune disorders. As imbalances in immune function affect other physiological processes, immunomodulators may have an important role in restoring and maintaining regular neuroimmue activities. In recent years these agents have demonstrated important benefits in controlling the mechanisms associated with deteriorating central nervous system pathologies such as Multiple Sclerosis (MS), where central and peripheral nervous system immune regulation is impaired. MS is characterized by severe compromises to neuroimmune processes involving changes in immune cell function, soluble proteins and modulation of inflammatory processes. The introduction of therapeutic agents in the form of immunomodulators; interferon, …
Criticisms Of African Trials Fail To Withstand Scrutiny: Male Circumcision Does Prevent Hiv Infection, Richard Wamai, Brian Morris, Jake Waskett, Edward Green, Joya Banerjee, Robert Bailey, Jeffrey Klausner, David Sokal, Catherine Hankins
Criticisms Of African Trials Fail To Withstand Scrutiny: Male Circumcision Does Prevent Hiv Infection, Richard Wamai, Brian Morris, Jake Waskett, Edward Green, Joya Banerjee, Robert Bailey, Jeffrey Klausner, David Sokal, Catherine Hankins
Richard G. Wamai
A recent article in the JLM (Boyle GJ and Hill G, "Sub-Saharan African Randomised Clinical Trials into Male Circumcision and HIV Transmission: Methodological, Ethical and Legal Concerns" (2011) 19 JLM 316) criticises the large randomised controlled trials (RCTs) that scientists, clinicians and policy-makers worldwide have concluded provide compelling evidence in support of voluntary medical male circumcision (VMMC) as an effective HIV prevention strategy. The present article addresses the claims advanced by Boyle and Hill, demonstrating their reliance on outmoded evidence, outlier studies, and flawed statistical analyses. In the current authors' view, their claims portray misunderstandings of the design, execution and …
Emerging Infectious Disease Surveillance In Southeast Asia: Cambodia, Indonesia, And The Naval Area Medical Research Unit 2, Sophal Ear
Sophal Ear
No abstract provided.
Malignant Peripheral Nerve Sheath Tumor (Mpnst): An Overview With Emphasis On Pathology, Imaging And Management Strategies., Timothy C. Beer
Malignant Peripheral Nerve Sheath Tumor (Mpnst): An Overview With Emphasis On Pathology, Imaging And Management Strategies., Timothy C. Beer
Timothy C Beer
MPNSTs are rare malignancies that are classically associated with pre-existing plexiform neurofibromas in neurofibromatosis type 1 (NF-1) patients, but also occur in association with radiation as well as sporadically in patients with no known risk factors. The typical presentation of sporadic MPNST is a new painless enlarging mass. The typical presentation of MPNST in an NF-1 patient is rapid enlargement or new onset of pain associated with a pre-existing plexiform neurofibroma. Although both MPNST and benign neurofibromas share in common the absence of neurofibromin function due to loss of both NF-1 alleles, malignant transformation to MPNST requires several additional aberrations, …
Backcalculation Of Hiv Infection Rates, Peter Bacchetti, Mark Segal, Nicholas Jewell
Backcalculation Of Hiv Infection Rates, Peter Bacchetti, Mark Segal, Nicholas Jewell
Mark R Segal
Backcalculation is an important method of reconstructing past rates of human immunodeficiency virus (HIV) infection and for estimating current prevalence of HIV infection and future incidence of acquired immunodeficiency syndrome (AIDS). This paper reviews the backcalculation techniques, focusing on the key assumptions of the method, including the necessary information regarding incubation, reporting delay, and models for the infection curve. A summary is given of the extent to which the appropriate external information is available and whether checks of the relevant assumptions are possible through use of data on AIDS incidence from surveillance systems. A likelihood approach to backcalculation is described …
Kenya Keen On Achieving Targets On Neglected Diseases, Richard Wamai
Kenya Keen On Achieving Targets On Neglected Diseases, Richard Wamai
Richard G. Wamai
No abstract provided.
'So It's Always A Dance': The Politics Of Gifts And Governance At A Drop-In Centre For Vulnerable Women In London, Ontario, Treena Orchard, Sara Farr, Susan Macphail
'So It's Always A Dance': The Politics Of Gifts And Governance At A Drop-In Centre For Vulnerable Women In London, Ontario, Treena Orchard, Sara Farr, Susan Macphail
Dr. Treena Orchard
No abstract provided.