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Full-Text Articles in Medicine and Health Sciences
Intracranial Eeg Patient Analysis: Seizure Reduction In Refractory Epilepsy Following Depth Electrode Insertion, Shreyashish Roy-Chowdhury
Intracranial Eeg Patient Analysis: Seizure Reduction In Refractory Epilepsy Following Depth Electrode Insertion, Shreyashish Roy-Chowdhury
Undergraduate Student Research Internships Conference
Rationale: The implantation effect describes an immediate reduction in seizure frequency following the insertion of intracranial electrodes. There is limited information regarding which patients will experience a reduction of seizures and the reason for the implantation effect. This study focuses on describing predictor factors for the reduction in seizure frequency in patients with medically resistant epilepsy implanted with depth electrodes.
Methods: We conducted a retrospective chart review of 89 patients who underwent intracranial electroencephalography (iEEG) monitoring with depth electrodes. Sixty-five of these patients had no subsequent therapeutic interventions and had a 3-6 month follow-up. Patients were grouped as either responders …
Characterizing The Heterogeneity Of Adult-Onset Leukoencephalopathy With Axonal Spheroids: A Digital Spatial Profiling Study, Peter Liu
Undergraduate Student Research Internships Conference
Adult-onset leukoencephalopathy with axonal spheroids (ALAS) is a group of hereditary, progressive, neurodegenerative disorders involving primarily the central nervous system white matter (WM). ALAS is characterized by patchy, asymmetrical myelin loss and axonal destruction in the WM, predominantly involving the frontoparietal regions. However, the asymmetrical and heterogenous involvement of different brain regions remains poorly characterized.
In this study, digital spatial profiling was performed to investigate the region-specific expressions of 60 proteins. Conventional immunohistochemistry methods was used validate intrepretation of probes. Using a high-plex and high-throughput method, we provide evidence of regional heterogeneity in ALAS, particularly involving key markers of microglia …