Medicine and Health Sciences Commons^™

Impact Of Acute Exercise On Micrornas Related To Concussion Symptoms, Emily Work

UNO Student Research and Creative Activity Fair

Impact of acute exercise on microRNAs related to concussion symptoms

Concussions, or traumatic brain injury (TBI), are a serious medical problem affecting approximately 1.7 million people in the United States each year. Current tools for analysis of concussion include the Glasgow Coma Scale, SCAT5, computerized topography (CT) and magnetic resonance imaging (MRI), however, these tools are typically not indicative of the range and severity of symptoms a patient may experience. Recent studies have explored the use of microRNAs as a biomarker for TBI severity in patients who have already experienced a TBI. We seek to investigate the microRNA levels in …

Studies Of Amino Acid Mutations In Drug Resistance Of The Smo Protein, Eunice Wintona

UNO Student Research and Creative Activity Fair

Smoothened receptor (SMO) is a protein that in humans, is encoded by the SMO gene. A systemic mutation in its binding pocket helps predict the sensitivity of mutant proteins to different drugs. Known as a GPCR-like receptor, it is a component of the hedgehog signaling pathway; a pathway involved in body patterning and the regulation of adult stem cells. An uncontrolled or inappropriate activation of the Hedgehog pathway drives tumor progression in cancers and a number of birth defects. To achieve these goals, the molecular modeling software MOE was used to build small molecules and drug molecules like Vismodegib and …

Modification Of The Ruiz-Moreno Chikungunya Seir Model, Joseph Devlin

UNO Student Research and Creative Activity Fair

The Ruiez-Moreno CHIKV model predicts the outcome of the Chikungunya disease. Chikungunya, a disease similar to the Zika virus, is vector-borne with very little treatment for patients. This experiment looks to find ways to improve the model. The model will still need further improvement, as there is no model that can predict with full certainty. However, a method of modification has been made to expedite the process, the code has been rearranged for easy input and to minimize possibility of unwanted changes, and the control files for comparison have been created. The method to modify the model can be superimposed …