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Full-Text Articles in Medicine and Health Sciences
Development Of A Functional In Vitro 3d Model Of The Peripheral Nerve, Wesley Anderson
Development Of A Functional In Vitro 3d Model Of The Peripheral Nerve, Wesley Anderson
Electronic Theses and Dissertations
Peripheral neuropathies, affect approximately 20 million people in the United States and are often a complication of conditions such as diabetes that can result in amputation of affected areas such as the feet and toes. In vitro methodologies to facilitate the understanding and treatment of these disorders often lack the cellular and functional complexity required to accurately model peripheral neuropathies. In particular, they are often 2-D and functional readouts, such as electrical activity, are limited to cell bodies thereby limiting the understanding of axonopathy which often characterizes these disorders. We have developed a functional 3-D model of peripheral nerves using …
Using Modeling And Simulation To Evaluate Disease Control Measures, Tracy Atkins
Using Modeling And Simulation To Evaluate Disease Control Measures, Tracy Atkins
Electronic Theses and Dissertations
This dissertation introduced several issues concerning the analysis of diseases by showing how modeling and simulation could be used to assist in creating health policy by estimating the effects of such policies. The first question posed was how would education, vaccination and a combination of these two programs effect the possible outbreak of meningitis on a college campus. After creating a model representative of the transmission dynamics of meningitis and establishing parameter values characteristic of the University of Central Florida main campus, the results of a deterministic model were presented in several forms. The result of this model was the …