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Dietetics and Clinical Nutrition
University of Nebraska - Lincoln
Department of Food Science and Technology: Faculty Publications
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Steps In Metagenomics: Let’S Avoid Garbage In And Garbage Out, Jacques Izard
Steps In Metagenomics: Let’S Avoid Garbage In And Garbage Out, Jacques Izard
Department of Food Science and Technology: Faculty Publications
Is metagenomics a revolution or a new fad? Metagenomics is tightly associated with the availability of next-generation sequencing in all its implementations. The key feature of these new technologies, moving beyond the Sanger-based DNA sequencing approach, is the depth of nucleotide sequencing per sample.1 Knowing much more about a sample changes the traditional paradigms of “What is the most abundant?” or “What is the most significant?” to “What is present and potentially significant that might influence the situation and outcome?” Let’s take the case of identifying proper biomarkers of disease state in the context of chronic disease prevention. Prevention …