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- A proposal for the mechanism of compression in the mandibular canal by separated endodontic file (1)
- Clinical assessment Diagnosis Imaging Morphometric analysis Radiology (1)
- Histomorphometry; nerve regeneration; nerve repair; scarring; sciatic nerve; PERIPHERAL-NERVE; LINGUAL NERVE; EPINEURIAL SUTURES; MYELINATED AXONS; SALIVARY-GLANDS; FIBRIN GLUE; REGENERATION; RAT; SIZE; CAT (1)
- Peripheral nerve regeneration; Nerve repair; Sciatic nerve; Scarring; TGF-beta; Mannose-6-Phosphate; CATWALK GAIT ANALYSIS; PERIPHERAL-NERVE; FUNCTIONAL RECOVERY; REGENERATION; COLLAGEN; INJURY; RAT; SITE; SURGERY; LESIONS (1)
- Peripheral nerve repair; nerve regeneration; scarring; triamcinolone acetonide; interleukin-10; mannose-6-phosphate; GROWTH-FACTOR-BETA; PERIPHERAL-NERVE; TRIAMCINOLONE ACETONIDE; INTRALESIONAL INJECTION; MESSENGER-RNA; SCHWANN-CELLS; REGENERATION; COLLAGEN; INJURY; INTERLEUKIN-10 (1)
Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Safe Zone For Bone Harvesting From The Interforaminal Region Of The Mandible, O. Al-Ani, P. Nambiar, K. O. Ha, W.C. Ngeow
Safe Zone For Bone Harvesting From The Interforaminal Region Of The Mandible, O. Al-Ani, P. Nambiar, K. O. Ha, W.C. Ngeow
Wei Cheong Ngeow
Aims: The mandibular incisive nerve can be subjected to iatrogenic injury during bone graft harvesting. Using cone beam computed tomography (CBCT), this study aims to determine a safe zone for bone graft harvesting that avoids injuring this nerve. Methods: Sixty CBCT examinations of patients were included in this study. The examinations were taken using the i-CAT CBCT imaging system, applying a standardized exposure protocol. Image reconstruction from the raw data was performed using the SimPlant dental implant software. The distances of mandibular incisive canal (MIC) to the inferior border and the labial and lingual cortices of the mandible were measured …
Histomorphometric Changes In Repaired Mouse Sciatic Nerves Are Unaffected By The Application Of A Scar-Reducing Agent, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson
Histomorphometric Changes In Repaired Mouse Sciatic Nerves Are Unaffected By The Application Of A Scar-Reducing Agent, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson
Wei Cheong Ngeow
Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural tissue that result from repair, and determine the effect of mannose-6-phosphate (M6P), a scar-reducing agent previously shown to enhance regeneration. In anaesthetised C57-black-6 mice, the left sciatic nerve was sectioned and repaired using four epineurial sutures. Either 100 mu L of 600 mM M6P (five animals) or 100 mu L of phosphate-buffered saline (placebo controls, five animals) was injected into …
The Effect Of Mannose-6-Phosphate On Recovery After Sciatic Nerve Repair, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson
The Effect Of Mannose-6-Phosphate On Recovery After Sciatic Nerve Repair, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson
Wei Cheong Ngeow
We have determined the effect of applying Mannose-6-Phosphate (M6P), a scar reducing agent, to a site of sciatic nerve repair. In anaesthetised C57-Black-6 mice, the left sciatic nerve was sectioned and repaired using 4 epineurial sutures. Either 100 mu l of 600 mM Mannose-6-Phosphate (29 animals), or 100 mu l of phosphate buffered saline as a placebo control (29 animals), was injected into and around the nerve repair site. A further group acted as sham-operated controls. After 6 or 12 weeks of recovery the extent of regeneration was assessed electrophysiologically and the percentage area of collagen staining at the repair …
A Comparison Between The Effects Of Three Potential Scar-Reducing Agents Applied At A Site Of Sciatic Nerve Repair, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson
A Comparison Between The Effects Of Three Potential Scar-Reducing Agents Applied At A Site Of Sciatic Nerve Repair, W.C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson
Wei Cheong Ngeow
We have investigated the effect of three potential scar-reducing agents applied at a sciatic nerve repair site in C57-black-6 mice. Under anaesthesia the nerve was transected, repaired using four epineurial sutures, and 100 mu l of either triamcinolone acetonide (1 mg/100 mu l), an interleukin-10 peptide fragment: (125 ng/100 mu l or 500 ng/100 mu l) or mannose-6-phosphate (M6P, 200 mM or 600 mM) was injected into and around the nerve. After 6 weeks the extent of regeneration was assessed electrophysiologically by determining the ratio of the compound action potential (CAP) modulus evoked by electrical stimulation of the nerve 2 …
Decompression Of Inferior Alveolar Nerve: Case Report Comment, W.C. Ngeow
Decompression Of Inferior Alveolar Nerve: Case Report Comment, W.C. Ngeow
Wei Cheong Ngeow
Paresthesia as a result of mechanical trauma is one of the most frequent sensory disturbances of the inferior alveolar nerve. This case report describes surgical treatment for paresthesia caused by a compressive phenomenon within the mandibular canal. The cause of the compression, a broken instrument left in the patient's mouth during previous endodontic therapy, was identified during routine radiography and computed tomography. Once the foreign object was removed by surgery, the paresthesia resolved quickly. This case highlights the potential for an iatrogenic mechanical cause of paresthesia.