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Curcumin Promotes Bone Marrow Stromal Cell Viability And Attenuates Tnf- -Induced Prostaglandin E2 Synthesis Via Cyclooxygenase-2 Suppression, Varittha Thongtan, Supaporn Suttamanatwong

Chulalongkorn University Dental Journal

Background Prostaglandin E2 (PGE2) is the main mediator for receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis and bone resorption in periodontitis. Bone marrow stromal cells (BMSCs) secrete PGE2 in response to pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). Curcumin, a polyphenolic compound from the turmeric plant, possesses an anti-inflammatory effect by downregulating key mediators of inflammation. Objectives This study examined the effect of curcumin on the process of PGE2 biosynthesis in TNF-α-stimulated BMSCs. Materials and methods To investigate curcumin cytotoxicity, mouse ST2 BMSCs were treated with 1-50 μM curcumin and cell viability was determined by the MTT assay. …