Medicine and Health Sciences Commons^™

Dental Hypotheses: Seeks To Publish Hypotheses From All Areas Of Dentistry, Edward F. Rossomando

UCHC Articles - Research

Starting a new open access journal in a rapid growing scientific panorama is a severe challenge. However, the first issue of dental hypotheses is now history and the even skeptics can appreciate that dental hypotheses is a success - it is a journal of high quality that provides an outlet for publication of articles that encourage readers to question dental paradigms. But dental hypotheses readers might have noticed that the majority of the articles published in the first issue of dental hypotheses concern clinical dentistry. However, dental hypotheses editors recognize that there are many other areas in dentistry that present …

Oral Mucositis: The New Paradigms, Rajesh V. Lalla, Douglas E. Peterson

UCHC Articles - Research

Purpose of review

Mucositis has long been viewed as an unavoidable consequence of high-dose chemotherapy and/or radiation. Management has been directed to supportive care including oral pain control, nutritional support, infection treatment and control of diarrhea. While these interventions have been valuable for clinical management, they have not been collectively directed to molecularly targeted prevention and treatment. This review addresses recent advances regarding mucosal injury in cancer patients, with emphasis on symptom clusters, genetically-based tissue susceptibility and risk prediction, imaging technology, and computational biology.

Recent findings

Modeling of symptom clusters in cancer patients continues to mature. Although integration of mucositis …

Characterization Of Stem And Progenitor Cells In The Dental Pulp Of Erupted And Unerupted Murine Molars, Anamaria Balic, Hector L. Aguila, Melissa J. Caimano, Victor P. Francone, Mina Mina

UCHC Articles - Research

In the past few years there have been significant advances in the identification of putative stem cells also referred to as “mesenchymal stem cells” (MSC) in dental tissues including the dental pulp. It is thought that MSC in dental pulp share certain similarities with MSC isolated from other tissues. However, cells in dental pulp are still poorly characterized. This study focused on the characterization of progenitor and stem cells in dental pulps of erupted and unerupted mice molars. Our study showed that dental pulps from unerupted molars contain a significant number of cells expressing CD90+/CD45-, CD117+/CD45-, Sca-1+/CD45- and little if …

Welcome To Tomorrow, Edward F. Rossomando

UCHC Articles - Research

It is always a delight to see an idea become a reality. We recognized that there was a need for a dental journal for those to publish a tentative explanation for a phenomenon, an explanation that could be used as a basis for further investigation. Early in the planning, it was necessary to address the question: Is there a need for a journal for dental hypothesis? A detailed examination of dental journals now published revealed that most if not all published research findings - this research might be in various scientific disciplines or in education but all contained results of …