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Expression Of Human Tissue Kallikreins (Klks) In Polymorphous Low Grade Adenocarcinoma (Plga), Jacqueline M. Cox
Expression Of Human Tissue Kallikreins (Klks) In Polymorphous Low Grade Adenocarcinoma (Plga), Jacqueline M. Cox
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Polymorphous low grade adenocarcinoma (PLGA) is the second most common malignant salivary gland tumour of the minor salivary glands. Human tissue kallikreins (KLKs) are a family of highly conserved serine proteases expressed by various tissues throughout the body. KLKs have become powerful tumour markers for the diagnosis of the cancer patient (e.g. PSA (KLK3)). The literature demonstrates a link between KLKs and salivary gland neoplasms. The purpose of this study is to determine levels of KLK mRNA in tissue samples of formalin fixed paraffin embedded polymorphous low grade adenocarcinoma (PLGA). Secondly, we wish to determine if KLK expression is limited …