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Preliminary Study Of Effects Of A Standardized Extract Of Centella Asiatica Eca 233 On Minor Aphthous Ulcers, Chalandakorn Ruengprasertkit, Naulchavee Hongprasong, Boonyong Tantisira, Mayuree H. Tantisira

Chulalongkorn University Dental Journal

Objective The present pilot study aimed to investigate the effects of a standardized extract of Centella asiatica ECa 233 on an oral paste form on minor recurrent aphthous ulceration (MiRAU). Materials and methods A randomized, single-blind, placebo controlled trial was conducted on 24 eligible subjects with MiRAU and randomly divided into four groups: 0.05, 0.10 and 0.20% ECa 233 paste and placebo oral paste. On entry to the trial at day 0, subjects were instructed to apply the oral paste three times per day (after breakfast and lunch and at bedtime) for 10 days or until the ulcer was completely …