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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Mastl Kinase, A Promising Therapeutic Target, Promotes Cancer Recurrence., Ling Wang, Vivian Q. Luong, Peter J. Giannini, Aimin Peng
Mastl Kinase, A Promising Therapeutic Target, Promotes Cancer Recurrence., Ling Wang, Vivian Q. Luong, Peter J. Giannini, Aimin Peng
Journal Articles: College of Dentistry
Mastl kinase promotes mitotic progression and cell cycle reentry after DNA damage. We report here that Mastl is frequently upregulated in various types of cancer. This upregulation was correlated with cancer progression in breast and oral cancer, poor patient survival in breast cancer, and tumor recurrence in head and neck squamous cell carcinoma. We further investigated the role of Mastl in tumor resistance using cell lines derived from the initial and recurrent tumors of the same head and neck squamous cell carcinoma patients. Ectopic expression of Mastl in the initial tumor cells strongly promoted cell proliferation in the presence of …
An In-Vitro Evaluation Of Mechanical And Esthetic Properties Of Orthodontic Sealants., Thyagaseely Sheela Premaraj, Nima Rohani, David Covey, Sundaralingam Premaraj, Yi Hua, Hidehiko Watanabe
An In-Vitro Evaluation Of Mechanical And Esthetic Properties Of Orthodontic Sealants., Thyagaseely Sheela Premaraj, Nima Rohani, David Covey, Sundaralingam Premaraj, Yi Hua, Hidehiko Watanabe
Journal Articles: College of Dentistry
OBJECTIVE: To evaluate mechanical and esthetic Properties of two commercially available orthodontic sealants: Opal(®)Seal (OS) and L.E.D. Pro Seal (PS).
MATERIALS AND METHODS: Discs of each sealant were prepared to test the following properties: Micro hardness, wear resistance and color stability. Samples were randomly selected after the wear test for SEM imaging to analyze surface morphology.
RESULTS: OS was significantly harder than PS (P < 0.001). PS was significantly more wear resistant than OS (P < 0.05). PS showed a greater ∆E*ab (increased staining) when placed in wine or coffee showing a significant difference (P < 0.05). SEM showed particle size, shape and distribution were different for PS and OS reflecting the pattern seen on wear surfaces.
CONCLUSION: Both orthodontic sealants are beneficial for protecting enamel. However with better wear properties PS was superior in resisting mechanical stresses. OS was more color stable.