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Malignant Hyperthermia, Kathryn Hernandez
Malignant Hyperthermia, Kathryn Hernandez
Nursing Student Class Projects (Formerly MSN)
Malignant hyperthermia (MH) is a condition in which the body goes into a hypermetabolic state affecting skeletal muscle in response to receiving inhaled anesthetics or the neuromuscular blocking agent, succinylcholine. MH is an autosomal dominant disorder that is most closely related to a defect in the ryanodine receptor. The defective receptor causes a rapid increase of intracellular calcium causing hyperthermia, tachycardia, tachypnea, hypercapnia, increased oxygen consumption, acidosis, hyperkalemia, muscle rigidity, and rhabdomyolysis. With the complexity of this disorder and its unique pathophysiological process it is crucial that all parts of the surgical team, especially anesthesia providers, understand how to treat …
Malignant Hyperthermia, Garrett Erickson
Malignant Hyperthermia, Garrett Erickson
Nursing Student Class Projects (Formerly MSN)
Malignant hyperthermia is known as a pharmacogenetic disorder which manifests itself in the skeletal muscle (Heytens, Forget, Scholtès, & Veyckemans, 2015). When a susceptible patient, who carries the autosomal dominant trait, is exposed to volatile anesthetics and/or the neuromuscular blocker succinylcholine, a detrimental response can occur. This response is a hypermetabolic state with hypercapnia, hemodynamic instability, rigidity, hyperthermia, and signs of rhabdomyolysis (Heytens et al., 2015). MH is a rare condition with incidences between 1/5,000 and 1/50,000 (Nagelhout and Plaus, 2014, p. 829), and often occurs during the induction of anesthesia but can also occur intraoperatively or one hour post …