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Full-Text Articles in Medicine and Health Sciences
Alterations In Rhythmic Licking Behaviors Following Fibrosis In The Rat Mylohyoid Muscle., Brittany Fletcher
Alterations In Rhythmic Licking Behaviors Following Fibrosis In The Rat Mylohyoid Muscle., Brittany Fletcher
Electronic Theses and Dissertations
Muscle injury is a common side effect of radiation treatment for head and neck cancer. To increase understanding of muscle injury related dysfunction, we investigated the effects of oral swallowing function after cryoinjury to mylohyoid muscle in rats. The hypothesis is that injury to the mylohyoid delays the temporal licking pattern, resulting in aberrant drinking behaviors. Six rats received bilateral mylohyoid injuries by applying a 3mm cryoprobe. Licking behavior was measured by electrophysiological recordings of rhythmic tongue movements in a ten-minute drinking session taken pre-and post-injury (one-and two-weeks). Lick frequency and total licks per cluster decreased significantly one-and two-weeks post-injury …
Swallow And Breathing Coordination Following Suprahyoid Muscle Injury., Bradley Kimbel
Swallow And Breathing Coordination Following Suprahyoid Muscle Injury., Bradley Kimbel
Electronic Theses and Dissertations
Swallowing motility disorders (dysphagia) are a major complication following radiation treatment for head and neck cancer, affecting ~50% of those treated. One reason for this is that radiation causes muscle damage, provoking sensorimotor pathologies. Previous work has suggested that injury may cause discoordination between breathing and swallowing behaviors. We sought to determine if muscle injury provokes changes in this behavior. We hypothesized that acute suprahyoid muscle damage would alter cross-behavior excitability, causing destabilization of the respiratory-swallow pattern. Swallowing was evoked in anesthetized spontaneously breathing cats via injection of a 3cc bolus of water into the oropharyngeal cavity. A suprahyoid injury …