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Full-Text Articles in Medicine and Health Sciences
The Role Of Candidate-Gene Cntnap2 In Childhood Apraxia Of Speech And Specific Language Impairment, Tracy M. Centanni, J. N. Sanmann, J. R. Green, Jenya Iuzzini-Seigel, Christopher W. Bartlett, W. G. Sanger, Tiffany P. Hogan
The Role Of Candidate-Gene Cntnap2 In Childhood Apraxia Of Speech And Specific Language Impairment, Tracy M. Centanni, J. N. Sanmann, J. R. Green, Jenya Iuzzini-Seigel, Christopher W. Bartlett, W. G. Sanger, Tiffany P. Hogan
Speech Pathology and Audiology Faculty Research and Publications
Childhood apraxia of speech (CAS) is a debilitating pediatric speech disorder characterized by varying symptom profiles, comorbid deficits, and limited response to intervention. Specific Language Impairment (SLI) is an inherited pediatric language disorder characterized by delayed and/or disordered oral language skills including impaired semantics, syntax, and discourse. To date, the genes associated with CAS and SLI are not fully characterized. In the current study, we evaluated behavioral and genetic profiles of seven children with CAS and eight children with SLI, while ensuring all children were free of comorbid impairments. Deletions within CNTNAP2 were found in two children with CAS but …