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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
The Famous Names Discrimination Task As A Biomarker Of Alzheimer's Disease Risk: An Erp Study, Elizabeth Rose Paitel
The Famous Names Discrimination Task As A Biomarker Of Alzheimer's Disease Risk: An Erp Study, Elizabeth Rose Paitel
Master's Theses (2009 -)
Current ERP research emphasizes age- and pathology-related declines in neural processing in the form of attenuated amplitudes and prolonged latencies. Notably, there is a gap in the ERP literature regarding neural processing trajectories in the time between healthy young adulthood and clinical MCI/AD samples. fMRI research, however, has demonstrated periods of increased, compensatory activation in healthy, cognitively intact APOE ɛ4 carriers both during resting state and event-related tasks (Bondi, Houston, Eyler, & Brown, 2005; Evans et al., 2014; Filippini et al., 2009; Rao et al., 2015), consistent with compensatory theories of cognitive aging (Cabeza, 2002; Park & Reuter-Lorenz, 2009; Reuter-Lorenz …
Aging, Executive Function, Fronto-Parietal Network Cortical Thickness: Insights From Cognitive Reserve, Katherine Reiter
Aging, Executive Function, Fronto-Parietal Network Cortical Thickness: Insights From Cognitive Reserve, Katherine Reiter
Dissertations (1934 -)
Cognitive reserve (CR) indexes the nonlinear relationship between neurological insult and behavioral change. CR is manifested in both static factors (e.g., childhood environment, education) and modifiable lifestyle factors, (e.g., leisure activities). Detailed investigation of the influence of CR on cortical thickness, which indexes neuropathology, and cognitive functioning could be particularly important in understanding the heterogeneity of Alzheimer’s disease (AD). While memory decline is the hallmark of AD, executive functioning (EF) decline often predates memory changes, making EF an important target for investigating CR influences. The current study examines the relationship of CR and genetic risk for AD (ε4) on EF …
Objective And Subjective Influences On Cognitive Performance In Adolescents With Type 1 Diabetes, Natalie E. Benjamin
Objective And Subjective Influences On Cognitive Performance In Adolescents With Type 1 Diabetes, Natalie E. Benjamin
Master's Theses (2009 -)
Type 1 diabetes mellitus (T1DM) is an increasingly common chronic illness in children and adolescents that can result in short- and long-term health complications. Disease management can be a particular challenge for adolescents seeking autonomy from caregivers. Recently, there has been a significant increase in adolescents’ use of diabetes-related technology to aid in blood glucose (BG) management and insulin administration. Individuals with T1DM also experience symptoms related to their BG levels, and these symptoms can serve as indicators of out-of-range BG levels and guide management decisions. Although research shows that diabetes-related health factors can affect cognitive functioning, no existing research …
Video Game Interventions To Improve Cognition In Older Adults, David E. C. Marra
Video Game Interventions To Improve Cognition In Older Adults, David E. C. Marra
Master's Theses (2009 -)
Cognitive abilities decline as part of the normal aging process. Various non-pharmacological interventions are being studied in an effort to ameliorate this cognitive decline. Some of these interventions include computerized cognitive training, such as neuropsychological software (i.e., brain training games) and video games. A previous study in our lab found that older adults who played a brain training game or a video poker game showed similar cognitive gains. The purpose of the present study was to follow the methodological procedures of our previous study to try and determine if the positive effects seen for the brain training program and video …
Reinforcement Learning, Error-Related Negativity, And Genetic Risk For Alzheimer's Disease, Christina Marie Figueroa
Reinforcement Learning, Error-Related Negativity, And Genetic Risk For Alzheimer's Disease, Christina Marie Figueroa
Dissertations (1934 -)
Reinforcement learning (RL) has been widely used as a model of animal and human learning and decision-making. The neural networks underlying RL involve many of the same structures primarily affected by Alzheimer’s disease (AD) such as the hippocampus. Yet, RL and non-invasive evaluation of its neural underpinnings have been underutilized as a framework for understanding disease pathology and its pre-clinical states. This study aimed to provide a novel approach for assessing subtle changes in asymptomatic apolipoprotein-E (APOE) carriers and non-carriers. Electroencephalography was collected from forty APOE genotyped older adults (Male n = 11; Mage = 79.30; Meducation = 14.88 years) …