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Effect Of Type 2 Diabetes On The Dynamic Response Characteristics Of Leg Vascular Conductance During Exercise, Oscar Mac Ananey, H Reilly, D O'Shea, M Egana, S Green
Effect Of Type 2 Diabetes On The Dynamic Response Characteristics Of Leg Vascular Conductance During Exercise, Oscar Mac Ananey, H Reilly, D O'Shea, M Egana, S Green
Articles
Abstract
In this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent contractions of the calf muscle in subjects with type 2 diabetes (n = 9), heavy controls (n = 10) and lean controls (n = 8) using a biexponential function and an estimate of the mean response time (MRT). The time constant of the second phase of LVC was significantly greater in type 2 diabetes (66.4 ± 29.2 s) than the heavy (22.2 ± 13.4 s) and …
Cardiac Output Is Not Related To The Slowed O2 Uptake Kinetics In Type 2 Diabetes, Oscar Mac Ananey, J Malone, S Warmington, D O'Shea, S Green, M Egana
Cardiac Output Is Not Related To The Slowed O2 Uptake Kinetics In Type 2 Diabetes, Oscar Mac Ananey, J Malone, S Warmington, D O'Shea, S Green, M Egana
Articles
Abstract
PURPOSE:
This study aimed to investigate whether cardiac output (CO) responses were related to VO2 kinetics during cycling in type 2 diabetes.
METHODS:
A total of 9 middle-aged women with uncomplicated type 2 diabetes, 9 nondiabetic overweight women, and 11 nondiabetic lean women were recruited. Initially, the ventilatory threshold (VT) and peak VO2 were determined during a maximal graded test. Then, on two separate days, subjects completed three 7-min bouts of constant-load cycling at each of three intensities: 50% VT, 80% VT, and midpoint between VT and peak VO2 (50% Δ). CO (inert gas rebreathing) was recorded at 30 …