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New Antimuscarinic Agents For Improved Treatment Of Poisoning By Cholinesterase Inhibitors, Robert Lee Hudkins

Theses and Dissertations

Poisoning by organophosphate cholinesterase inhibitors results in a rapid rise in acetylcholine (ACh) in the synapse and many pronounced pharmacological effects in numerous tissues in the body. The treatment for organophosphorus poisoning involves administration of a cholinesterase—reactivating oxime to restore the activity of the cholinesterase and an antimuscarinic agent to block the response to the excess ACh. Presently atropine is the standard antimuscarinic agent used clinically as an antidote. This research was directed toward finding an antimuscarinic agent better than atropine as an antidote.

Since caramiphen and aprophen have been reported to be effective antidotes we synthesized numerous structural variations …