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Is Iron Sucrose (Venofer) A Safe Treatment For People With Chronic Kidney Disease?, Kait Reid
Is Iron Sucrose (Venofer) A Safe Treatment For People With Chronic Kidney Disease?, Kait Reid
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this study is to determine if Iron Sucrose (Venofer) is a safe treatment for people with Chronic Kidney Disease.
Identification Of Novel Allosteric Regulators Of Human Erythrocyte Pyruvate Kinase, Shilpa S. Kharalkar
Identification Of Novel Allosteric Regulators Of Human Erythrocyte Pyruvate Kinase, Shilpa S. Kharalkar
Theses and Dissertations
Erythrocyte pyruvate kinase (R-PK) is a key glycolytic enzyme catalyzing the transphosphorylation of phosphoenolpyruvate (PEP) and ADP to pyruvate and ATP respectively3,4. The substrate PEP and product pyruvate of this reaction are involved in a number of energetic and biosynthetic pathways; hence a tight regulation of R-PK activity is crucial not only for glycolysis, but also for the entire cellular metabolism. Deficiency of R-PK is one of the most common enzymatic defects of RBC, and may be caused by mutations of the PK-LR (pyruvate kinase liver red blood cell) gene31, 32. Clinically, R-PK deficiency manifests itself as a chronic life-long …