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Full-Text Articles in Medicine and Health Sciences
Screening Assay For Enzymes Involved In Pathophysiology Using Seldi-Tof Mass Spectrometr, Khalid M. Elased, Mariana Morris
Screening Assay For Enzymes Involved In Pathophysiology Using Seldi-Tof Mass Spectrometr, Khalid M. Elased, Mariana Morris
Pharmacology and Toxicology Faculty Publications
The invention provides methods for quantifying enzymatic activity of an enzyme with a known substrate. The methods employ SELDI-TOF mass spectrometry, and are suitable, in particular, for assaying aspects of the renin-angiotensin system. The methods may be utilized to assess and/or monitor biological conditions associated with the renin-angiotensin system prior to the manifestation of known physiological and biomarkers for such conditions. The methods are suitable for analysis of pharmacological effectors of the renin-angiotensin system, and are particularly suitable for automation and high-throughput screening assay design.
Screening Assay For Inhibitors Of Severe Acute Respiratory Syndrome (Sars) Using Seldi-Tof Mass Spectrometry, Khalid M. Elased, Mariana Morris
Screening Assay For Inhibitors Of Severe Acute Respiratory Syndrome (Sars) Using Seldi-Tof Mass Spectrometry, Khalid M. Elased, Mariana Morris
Pharmacology and Toxicology Faculty Publications
Mass spectrometric methods directed to screening libraries of compounds for agents that inhibit entry of Severe Acute Respiratory Syndrome (SARS) coronavirus (CoV) into cells are provided, along with methods for comparatively evaluating inhibitors of the SARS CoV.