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Full-Text Articles in Medicine and Health Sciences
Differential Control Of Tgm2 Expression By Oestrogen Receptor/Serms., Damian Lally
Differential Control Of Tgm2 Expression By Oestrogen Receptor/Serms., Damian Lally
Masters
Breast cancer is a malignancy of the epithelial cells comprising the mammary gland. As the ER is necessary for the growth of pproximately 70% of breast cancers, pharmaceutical efforts have focused on uncovering modulators of the ERα such as antiestrogens and Selective Oestrogen Receptor Modulator (SERMs). SERMs differ from pure ER antagonists in their capacity to display tissue-selective and C promoter dependent agonist-antagonist activities. Tamoxifen (TAM) is a SERM that is used in the treatment of hormonally responsive breast cancer. TAM is the most commonly used treatment for patients with ERα positive breast cancer. In this study we examined the …
Ecotoxicological Investigations Of Pharmaceutical Compounds On A Battery Of Freshwater Test Species., Elaine Minagh
Ecotoxicological Investigations Of Pharmaceutical Compounds On A Battery Of Freshwater Test Species., Elaine Minagh
Masters
Currently interest in pharmaceuticals as potential environmental contaminants has increases significantly. This is due to the awareness of the possible adverse effects to human health and the environment caused by such contaminants. Within the past few years, the highly prescribed antidepressants, selective serotonin reuptake inhibitors (SSRI), have received attention as their occurrence in the environment has been recently documented. Prior to this, there was very little known about the ecotoxicity of SSRIs, and in particular sertraline hydrochloride. Similarly the cholesterol-lowering drugs, known as statins are among the most frequently prescribed agents in Ireland and worldwide for the treatment of coronary …
Phenmedipham Process Development, Maura Byrne
Phenmedipham Process Development, Maura Byrne
Masters
The objective of this work was to investigate the process for the production of an organic herbicide, phenmedipham, utilising isobutylacetate as solvent and to scale up the reaction to one litre. This was carried out according to a technical bulletin received from Barclay Plant Protection Ltd. Difficulties were encountered in isolating the product, methyl N-(3-hydroxyphenyl) carbamate, from stage 1 with isobutylacetate as solvent. An investigation of the use of other solvents for the reaction process led to the use of ethyl acetate, in a modified version of the method used by Schering A-G, and resulted in a 93% yield of …