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Electrochemical Deposition Of Calcium Phosphate-Based Coatings Onto Porous Ti Using Organic Phosphorus Sources, Clement Lee Jul 2022

Electrochemical Deposition Of Calcium Phosphate-Based Coatings Onto Porous Ti Using Organic Phosphorus Sources, Clement Lee

Electronic Thesis and Dissertation Repository

The study and commercialization of calcium phosphate (Ca-P) coatings has occurred for several decades. However, this has typically involved the use of hydroxyapatite. This thesis presents the synthesis of different Ca-P-based coatings that has not been studied. Anodic oxidation was employed to create a porous Ti substrate, while pulsed electrochemical deposition was used to deposit the coating onto the Ti. The first coating synthesized was a calcium phosphoserine (Ca-pSer) complex, which contained two different morphologies: a flower-like structure at low deposition time and a unique cubic morphology at higher deposition times. Next, an amorphous calcium phosphate coating was synthesized and …


The Role Of Reactive Oxygen Species In The Accumulation Of Driver Mutations In B Cell Acute Lymphoblastic Leukemia, Mia P. Sams Jun 2022

The Role Of Reactive Oxygen Species In The Accumulation Of Driver Mutations In B Cell Acute Lymphoblastic Leukemia, Mia P. Sams

Electronic Thesis and Dissertation Repository

B cell acute lymphoblastic leukemia (B-ALL) is the most prevalent type of cancer in young children and is associated with recurrent mutations and high levels of reactive oxygen species (ROS). The antioxidant N-acetylcysteine was tested for its ability to prolong lifespan of a mouse model of B-ALL and reduce frequency of mutations. Mice treated with 1g/L of N-acetylcysteine in drinking water were found to have delayed onset of B-ALL at 11 weeks of age and changes in gene expression relating to B cell development, calcium-apoptosis signaling, and pathways in cancer, although no differences in lifespan were observed. Tumours from treated …


Seeing Thro The Musical Eye: Santo Daime, Fuke-Shū, 1960s Psychedelia, And The Antipodes Of Musical Experience, Forest Anthony-Muran Apr 2022

Seeing Thro The Musical Eye: Santo Daime, Fuke-Shū, 1960s Psychedelia, And The Antipodes Of Musical Experience, Forest Anthony-Muran

Electronic Thesis and Dissertation Repository

This thesis investigates the relationships between altered states of consciousness and the musical experience in religious tradition and practice. A common accompaniment to religious worship and ceremony, music is often used as a way of attempting to capture something of the ineffable and to help bring about a mystical experience. In this thesis, I make use of three contrasting case studies – the Brazilian syncretic religion Santo Daime, the historical branch of Zen Buddhism Fuke-shū, and the psychedelic rock of 1960s counterculture – to paint a portrait of the variety of ways that music has been used in different musical …


The Role Of Coagulase-Negative Staphylococcal Secreted Products On Staphylococcus Aureus And Staphylococcus Lugdunensis Infections, Denny Chin Apr 2022

The Role Of Coagulase-Negative Staphylococcal Secreted Products On Staphylococcus Aureus And Staphylococcus Lugdunensis Infections, Denny Chin

Electronic Thesis and Dissertation Repository

The Staphylococcus genus is comprised of over 40 bacterial species. The most well-studied species in this genus is the notorious human pathogen Staphylococcus aureus, a bacterium that produces coagulase among many other virulence factors. Since S. aureus is a major health burden and causes a plethora of diseases in humans, it has received significant attention and much research has been done to understand its biology to treat diseases caused by this pathogen. However, the coagulase-negative staphylococci (CoNS) make up most of the staphylococcal species and have received less attention since they are thought to have a lesser impact on …