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Full-Text Articles in Medicine and Health Sciences
Interactions Between Estradiol, Bdnf And Dendritic Spines In Promoting Memory., V. Luine, M. Frankfurt
Interactions Between Estradiol, Bdnf And Dendritic Spines In Promoting Memory., V. Luine, M. Frankfurt
Journal Articles
Several lines of evidence have converged to indicate that memory formation involves plasticity of dendritic spines in the medial prefrontal cortex (PFC) and the hippocampus. Memory varies with estrogen levels throughout the lifespan of the female. Generally, increased levels of estrogen are related to greater dendritic spine density on pyramidal cells in the PFC and the hippocampus and to improved memory function. Brain-derived neurotrophic factor (BDNF) is a growth factor which increases dendritic spines and enhances memory function. Estrogens increase BDNF levels in the PFC and the hippocampus. In the present review we provide evidence that estradiol and BDNF may …
Ribosomally Synthesized And Post-Translationally Modified Peptide Natural Products: Overview And Recommendations For A Universal Nomenclature, P. G. Arnison, M. J. Bibb, G. Bierbaum, A. A. Bowers, T. S. Bugni, G. Bulaj, J. A. Camarero, D. J. Campopiano, J. M. Willey, W. A. Van Der Donk, +55 Additional Authors
Ribosomally Synthesized And Post-Translationally Modified Peptide Natural Products: Overview And Recommendations For A Universal Nomenclature, P. G. Arnison, M. J. Bibb, G. Bierbaum, A. A. Bowers, T. S. Bugni, G. Bulaj, J. A. Camarero, D. J. Campopiano, J. M. Willey, W. A. Van Der Donk, +55 Additional Authors
Journal Articles
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
Age-Dependent Effects Of A53t Alpha-Synuclein On Behavior And Dopaminergic Function, A. W. Oaks, M. Frankfurt, D. I. Finkelstein, A. Sidhu
Age-Dependent Effects Of A53t Alpha-Synuclein On Behavior And Dopaminergic Function, A. W. Oaks, M. Frankfurt, D. I. Finkelstein, A. Sidhu
Journal Articles
Expression of A53T mutant human alpha-synuclein under the mouse prion promoter is among the most successful transgenic models of Parkinson's disease. Accumulation of A53T alpha-synuclein causes adult mice to develop severe motor impairment resulting in early death at 8-12 months of age. In younger, pre-symptomatic animals, altered motor activity and anxiety-like behaviors have also been reported. These behavioral changes, which precede severe neuropathology, may stem from non-pathological functions of alpha-synuclein, including modulation of monoamine neurotransmission. Our analysis over the adult life-span of motor activity, anxiety-like, and depressive-like behaviors identifies perturbations both before and after the onset of disease. Young A53T …