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Experimental And Computational Analysis Of The Structure And Dynamics Of Intrinsically Disordered Proteins, Elio Anthony Cino
Experimental And Computational Analysis Of The Structure And Dynamics Of Intrinsically Disordered Proteins, Elio Anthony Cino
Electronic Thesis and Dissertation Repository
Intrinsically disordered proteins (IDPs) are abundant in cells and have central roles in
protein-protein interaction networks. Many are involved in cancer, aging and
neurodegenerative diseases. The structure and dynamics of IDPs is intimately related to their
interactions with binding partners. Because IDPs are inherently flexible and do not have a
single conformation, conventional methods and conditions for determining structure and
dynamics of globular proteins may not be directly applicable. Nuclear magnetic resonance
(NMR) spectroscopy is one of the primary techniques characterizing the structures and
dynamics of IDPs, but one cannot rely solely on NMR data. A primary aim of this …