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Kinetic Degradation Study Of Ipragliflozin Coupled With Ms/Ms Structural Elucidation, Shereen Mowaka, Manar M. Elhassan,, Amr M. Mahmoud, Maha A. Hegazy
Kinetic Degradation Study Of Ipragliflozin Coupled With Ms/Ms Structural Elucidation, Shereen Mowaka, Manar M. Elhassan,, Amr M. Mahmoud, Maha A. Hegazy
Pharmacy
Ipragliflozin degradation behavior was studied under different conditions: acidic, basic, photolytic, oxidative and thermal degradation conditions. This forced degradation study showed the extensive degradation of Ipragliflozin under acidic, basic and oxidative conditions while showed high stability under thermal and photo-degradation conditions. The separation of Ipragliflozin and its degradation products was done using Hypersil Gold® UPLC C18 column with 1.9 μm particle size (3 × 50 mm) as stationary phase and a mobile phase composed of acetonitrile: potassium monobasic phosphate buffer pH 3 (50:50; v/v) delivered at flow rate of 0.6 mL min−1. Validation of the proposed method was carried out …