Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Gold Ion–Angiotensin Peptide Interaction By Mass Spectrometry, Jenny Lee '13, Lasanthi P. Jayathilaka, Shalini Gupta, Jin-Sheng Huang, Bao- Shiang Lee
Gold Ion–Angiotensin Peptide Interaction By Mass Spectrometry, Jenny Lee '13, Lasanthi P. Jayathilaka, Shalini Gupta, Jin-Sheng Huang, Bao- Shiang Lee
Student Publications & Research
Stimulated by the interest in developing gold compounds for treating cancer, gold ion– angiotensin peptide interactions are investigated by mass spectrometry. Under the experimental conditions used, the majority of gold ion–angiotensin peptide complexes contain gold in the oxidation states I and III. Both ESI-MS and MALDI-TOF MS detect singly/multiply charged ions for mononuclear/multinuclear gold-attached peptides, which are represented as [peptide+a Au (I)+b Au(III)+(e - a -3b) H]e+, where a,b≥0 and e is charge. ESI-MS data shows singly/multiply charged ions of Au(I)-peptide and Au(III)-peptide complexes. This study reveals that MALDITOF MS mainly detects singly charged Au(I)-peptide complexes, presumably due to the …