Medicine and Health Sciences Commons^™

Preparation Of Supramolecular Amphiphilic Cyclodextrin Bilayer Vesicles For Pharmaceutical Applications, Kate E. Frischkorn

Master's Theses

Recent pharmaceutical developments have investigated using supramolecular nanoparticles in order to increase the bioavailability and solubility of drugs delivered in various methods. Modification of the carbohydrate cyclodextrin increases the ability to encapsulate hydrophobic pharmaceutical molecules by forming a carrier with a hydrophobic core and hydrophilic exterior. Guest molecules are commonly added to these inclusion complexes in order to add stability and further increase targeting abilities of the carriers. One such guest molecule is adamantine combined with a poly(ethylene glycol) chain. Vesicles are formed by hydrating a thin film of amphiphilic cyclodextrin and guest molecules in buffer solution that mimics physiological …

Part 1: Synthesis Of 3,7 Dimethyl-7-Methoxyoctane-2-Ol (Osyrol) From Citronellol Utilizing The Wacker Process Part 2: Developing A Methodology For C(Sp3)-H Arylation On The Β Position Of A Carboxylic Acid Using A Removable Directing Group, Stephen Lo

Master's Theses

The synthesis of 3,7-dimethyl-7-methoxyoctane-2-ol (Osyrol), an important sandalwood odorant, from 3,7-dimethylocta-1,6-diene (dihydromyrcene) was recently accomplished by two groups, both utilizing a two-step epoxide formation and ring opening approach. Here, the synthesis of Osyrol from 3,7-Dimethyloct-6-en-1-ol (citronellol) is accomplished in a novel six-step approach. The key steps in this synthesis is the Wacker Oxidation of a terminal double bond followed by sodium borohydride (NaBH₄) reduction. Though most of the steps in this reaction scheme resulted in limited success, the key steps occurred with high yields.

In the second chapter, the effects of 2-aminophenyl-1H-pyrazole (2-APP) as a removable directing group …