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- <p>Disulfiram.</p> <p>Staphylococcus aureus infections.</p> <p>Methicillin resistance.</p> <p>Antibacterial agents.</p> <p>High performance liquid chromatography.</p> <p>Thiamin pyrophosphate.</p> <p>Enzymes.</p> <p>Coenzymes.</p> <p>Biosynthesis.</p> <p>Amino acids -- Metabolism.</p> (1)
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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Effects Of Disulfiram On The Metabolome Of Mrsa, Surya Teja Naidu
Effects Of Disulfiram On The Metabolome Of Mrsa, Surya Teja Naidu
Theses, Dissertations and Capstones
Disulfiram, known as Antabuse®, is an oral drug for the treatment of alcohol dependence. Previous studies have indicated that disulfiram (DSF) exhibits antibacterial effects, particularly against Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Our study delves into the antibacterial mechanism of DSF in MRSA through High-Pressure Liquid Chromatography (HPLC) metabolomics, investigating the underlying mechanism of DSF effects on thiamine and amino acid metabolism. Thiamine pyrophosphate (TPP) plays a crucial role as a cofactor for critical enzymes such as transketolase, pyruvate dehydrogenase, and 2-oxoglutarate dehydrogenase. These enzymes are integral to the carbohydrate metabolism process within bacterial cells. TPP also contributes …
Prenatal Buprenorphine Exposure Reduces Expression Of Myelin Proteins In Neonatal Longs-Evans Rat, Christopher James Grahe
Prenatal Buprenorphine Exposure Reduces Expression Of Myelin Proteins In Neonatal Longs-Evans Rat, Christopher James Grahe
Theses, Dissertations and Capstones
In the USA and especially in WV, there has been a surge in the rise of opioid use disorder (OUD), and with it a rise in neonatal abstinence syndrome (NAS). What makes this rise in NAS so unfortunate is that the Medications for OUD (MOUD) do not prevent the development of NAS. Although the relationship between MOUD and NAS is still unclear, it is thought that buprenorphine, one of the main substances used to treat OUD in pregnant women, may feed into the development of NAS, which may affect mental and physiological development and cause other health problems. Via understanding …
The Opioid Epidemic: Effects On Recidivism In West Virginia, Emilee Frye, Elizabeth Williams
The Opioid Epidemic: Effects On Recidivism In West Virginia, Emilee Frye, Elizabeth Williams
Theses, Dissertations and Capstones
The opioid epidemic began in the 1990s with an increased prescribing of opioids across the nation. Between the years 2013 and 2014, opioid overdose death rates began to increase in West Virginia. By the year 2015, West Virginia held the highest number of opioid overdose death rates in the country. In 2021, fatal overdoses claimed more than 1,417 lives in West Virginia and of those 1,417, an estimated 1,201 of them were due to opioid use.
West Virginia had the highest opioid drug overdose rate in the nation and one of the highest incarceration rates for opioid-dependent individuals. West Virginia …