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The Synergistic Effect Of Loganetin And 5-Fluorouracil On The Carcinogenesis Of Glioblastoma Cancer Cells, Jonathan Wollenberg

ATU Research Symposium

Chemoresistance is a discouraging trend that affects chemotherapeutic agents like 5-fluorouracil (5-FU) and leads to decreased efficacy of treatment. This has led to numerous studies into compound synergism. Glioblastomas are a type of lethal cancer that has shown chemoresistance to therapeutic agents such as 5-fluorouracil. Being the most common and lethal primary brain tumor, research on mechanisms of growth inhibition is vastly important (Lustig, 2018). The purpose of this study was to analyze whether 5-fluorouracil and a compound named Loganetin could synergistically inhibit glioblastoma cancer cells. This specific study utilized an extract created from the Lonicera etrusca plant. It was …